Non Hodgkin Lymphoma Clinical Trial
Cardiovascular Reserve Evaluation in Survivors of Transplant, CREST Study
Summary
This study evaluates how well the heart, lungs, and muscles are working individually, and how these systems are working together in transplant survivors. Information collected in this study may help doctors to understand why hematopoietic stem cell transplant survivors are at higher risk for developing cardiovascular disease.
Full Description
PRIMARY OBJECTIVES:
I. Evaluate cardiovascular reserve capacity, as measured by peak oxygen consumption (VO2peak), in hematopoietic cell transplantation (HCT) survivors.
II. Define the determinants of VO2peak impairment in HCT survivors.
OUTLINE:
Patients undergo echocardiogram to assess cardiac function and mechanics, cardiopulmonary exercise test, pulmonary function test, musculoskeletal ultrasound, bioelectrical impedance analysis to measure total lean body mass and percent body fat), physical function tests, and collection of blood samples within 45 days from the start of conditioning therapy, and at 6 months, 1 year, and 2 years post-transplant.
Eligibility Criteria
Inclusion Criteria:
Age at HCT >= 18 years
Diagnosis of acute leukemia (myeloid, lymphoid), lymphoma (non-Hodgkin, Hodgkin), multiple myeloma or myelodysplastic syndromes
Planning to undergo first autologous or allogeneic transplant
Able to fluently read and write in English
Able to understand and sign the study specific informed consent form (ICF)
Physically able and willing to complete all study procedures
Exclusion Criteria:
Unstable bone lesions per electronic medical record review and/or notification from patient's primary physician
Unstable angina or history of acute myocardial Infarction (< 5 days of any planned study procedures)
Recurrent syncope
Acute myocarditis or pericarditis
Symptomatic severe aortic stenosis
Uncontrolled arrhythmia causing symptoms
Pulmonary embolus < 3 month of study procedures
Thrombosis of lower extremities
Moderate or severe persistent asthma (National Asthma Education & Prevention)
Room air desaturation at rest =< 85%
Non-cardiopulmonary disorders that may affect exercise performance or be aggravated by exercise (i.e. infection, renal failure, thyrotoxicosis)
Anemia (hemoglobin [Hgb] < 8 g/dL)
Check Your Eligibility
Let’s see if you might be eligible for this study.
What is your age and gender ?
There is 1 Location for this study
Duarte California, 91010, United States More Info
Principal Investigator
How clear is this clinincal trial information?