Non Hodgkin Lymphoma Clinical Trial

Connect® Lymphoma Disease Registry: A US-Based Prospective Observational Cohort Study

Summary

The Connect® Lymphoma Disease Registry is a US-based, multicenter, prospective observational (non-interventional) cohort study designed to collect real-world, participant-level data longitudinally in participants diagnosed with various subtypes of non-Hodgkin lymphoma (NHL).

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Full Description

This Disease Registry is designed to capture the patient characteristics, practice patterns, and therapeutic strategies evaluated in community and academic centers when treating relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL), and R/R follicular lymphoma (FL). The data collected in this Registry will facilitate the evaluation of the current treatment landscape for non-Hodgkin lymphoma (NHL), including the clinical effectiveness, safety. No investigational product or drug will be administered as part of this study. Enrolled patients will receive treatment and evaluations for their disease according to the standard of care and routine clinical practice at each study site. All treatments that patients receive for their disease will be recorded, including any previous lymphoma treatments. Clinical outcomes will be documented as part of an objective clinical assessment. In addition, patient-reported health-related quality of life (HRQoL) outcomes data will be collected from patients using various validated instruments. Social support data will also be collected.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Must be ≥18 years of age at the time of consent
Must be able to provide written informed consent personally or by legally authorized representative

Must have 1 of the following histologically confirmed Non-Hodgkin Lymphoma (NHL) subtypes:

Diffuse large B-cell lymphoma (DLBCL), NOS; or DLBCL high-grade lymphoma, not otherwise specified (NOS); or DLBCL high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements with DLBCL histology (double/triple-hit lymphoma)

Epstein-Barr virus-positive or composite DLBCL are allowed
Follicular lymphoma (FL)
Must have been previously treated with ≥ 1 prior systemic therapy (e.g., chemotherapy, immunotherapy, or chemoimmunotherapy)
For first relapsed/refractory (R/R) DLBCL cohort, participant must have confirmed R/R disease within 90 days prior to study enrollment and must intend to initiate 2L systemic treatment
For first R/R FL cohort, participant must have confirmed R/R disease (grade 1 to 3B or transformed) within 90 days prior to study enrollment and must intend to initiate 2L systemic treatment
Participant must be willing and able to complete enrollment and follow-up health-related quality of life (HRQoL) and social support instruments
Participants volunteering for the Tissue Sub-Study must consent for use of their blood/tumor biopsies, which were collected as per standard of care, for exploratory analyses

Exclusion Criteria:

Participant whose prior start and end date of DLBCL or FL treatment, and prior treatment received, including chemotherapy, radiation, surgery (not including excisional biopsies), and other anticancer therapy, are unknown
Participant who has any other active malignancy (non-DLBCL or non-FL) for which the participant is receiving treatment at the time of enrollment or any other former malignancy that was diagnosed within 6 months prior to Registry enrollment (with the exception of non-melanoma skin cancer)
Currently enrolled in any interventional clinical trial where the participant is being treated with an investigational product that cannot be identified

Study is for people with:

Non Hodgkin Lymphoma

Estimated Enrollment:

1000

Study ID:

NCT04982471

Recruitment Status:

Recruiting

Sponsor:

Celgene

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There are 47 Locations for this study

See Locations Near You

Genesis Cancer Center
Hot Springs Arkansas, 71913, United States
VA Central California Health Care System - NAVREF - PPDS
Fresno California, 93703, United States More Info
Yuankai Lin, Site 129
Contact
559-225-6100
Pacific Cancer Care
Monterey California, 93940, United States
Rocky Mountain Cancer Centers (Boulder) - USOR
Boulder Colorado, 80303, United States More Info
David Andorsky, Site 160
Contact
303-388-4876
University of Florida College of Medicine Jacksonville
Jacksonville Florida, 32209, United States More Info
Walter Quan, Site 145
Contact
252-816-2560
Cancer Specialists Of North Florida
Jacksonville Florida, 32256, United States
Woodlands Medical Specialists, PA
Pensacola Florida, 32503, United States More Info
Rami Owera, Site 158
Contact
850-696-0147
Woodlands Medical Specialists, Pa
Pensacola Florida, 32503, United States
Bond Clinic, P.A.
Winter Haven Florida, 33881, United States
Harbin Clinic
Rome Georgia, 30165, United States More Info
Dilawar Khan, Site 104
Contact
706-235-5875
Summit Cancer Care, PC
Savannah Georgia, 31401, United States
Summit Cancer Care, PC
Savannah Georgia, 31401, United States More Info
Mark Taylor, Site 112
Contact
912-692-6194
Cotton O'Neil Clinical Research, Hematology and Oncology
Topeka Kansas, 66606, United States
Cotton O'Neil Clinical Research, Hematology and Oncology
Topeka Kansas, 66606, United States More Info
Daulath Singh, Site 133
Contact
Tulane University Health Sciences Center
New Orleans Louisiana, 70112, United States More Info
Nakhle Saba, Site 152
Contact
504-988-5482
Local Institution - 134
Lewiston Maine, 04240, United States
Regional Cancer Care Associates
Bethesda Maryland, 20817, United States
UPMC Western Maryland Corporation
Cumberland Maryland, 21502, United States
UPMC Western Maryland Corporation
Cumberland Maryland, 21502, United States More Info
Blanche Mavromatis, Site 101
Contact
University Of Michigan Comprehensive Cancer Center
Ann Arbor Michigan, 48109, United States More Info
Tycel Phillips, Site 147
Contact
626-725-1208
University Of Minnesota
Minneapolis Minnesota, 55455, United States
Oncology Research, HealthPartners Institute
Saint Louis Park Minnesota, 55426, United States
Oncology Research, HealthPartners Institute
Saint Louis Park Minnesota, 55426, United States More Info
Dylan Zylla, Site 110
Contact
952-993-1290
Harry S. Truman Memorial Veterans' Hospital (HSTMVH) - NAVREF - PPDS
Columbia Missouri, 65201, United States More Info
Suzanne Patton, Site 144
Contact
Mercy Clinic Oncology and Hematology - Joplin
Joplin Missouri, 64804, United States More Info
Samir Dalia, Site 119
Contact
417-556-3063
Saint Louis University
Saint Louis Missouri, 63110, United States More Info
Sagun Goyal, Site 120
Contact
314-577-8854
Local Institution - 162
Reno Nevada, 89511, United States
New Jersey Cancer Care
Belleville New Jersey, 07109, United States More Info
Orsini James, Site 163
Contact
973-751-8880
Astera Cancer Care East Brunswick
East Brunswick New Jersey, 08816, United States More Info
Mohammad Kazemi, Site 159
Contact
Summit Medical Group
Florham Park New Jersey, 07932, United States More Info
William DeRosa, Site 132
Contact
973-538-5210
Local Institution - 140
Freehold New Jersey, 07728, United States More Info
Site 140
Contact
RCCA - Little Silver Division
Little Silver New Jersey, 07739, United States More Info
Ian Horkheimer, Site 138
Contact
Atlantic Hematology Oncology - Morristown
Morristown New Jersey, 07960, United States
Rochester General Hospital - Lipson Cancer Institute
Rochester New York, 14621, United States
New York Medical College
Valhalla New York, 10595, United States
East Carolina University
Greenville North Carolina, 27858, United States More Info
Darla Liles, Site 151
Contact
252-744-2391
Cleveland Clinic Mercy Hospital
Canton Ohio, 44708, United States More Info
Mitchell Haut, Site 113
Contact
330-453-9993
Tri County Hematology Oncology
Canton Ohio, 44718, United States
Tri County Hematology Oncology
Canton Ohio, 44718, United States More Info
Noman Rafique, Site 111
Contact
330-837-2646
Local Institution - 156
Springfield Oregon, 97477, United States More Info
Site 156
Contact
Abramson Cancer Center Of The University Of Pennsylvania
Philadelphia Pennsylvania, 19066, United States More Info
Jakub Svoboda, Site 170
Contact
Fox Chase Cancer Center
Philadelphia Pennsylvania, 19111, United States
Reading Hospital
West Reading Pennsylvania, 19611, United States More Info
Terrence Cescon, Site 171
Contact
610-374-4404
Cancer Care Associates of York
York Pennsylvania, 17403, United States
Cancer Care Associates of York
York Pennsylvania, 17403, United States More Info
Chanh Huynh, Site 117
Contact
Charleston Oncology, P.A
Charleston South Carolina, 29414, United States
Thompson Cancer Survival Center
Knoxville Tennessee, 37916, United States
Brooke Army Medical Center - DoD - PPDS
Fort Sam Houston Texas, 78234, United States More Info
Michael Osswald, Site 125
Contact
210-916-6716
MD Anderson Cancer Center
Houston Texas, 77003, United States More Info
Dai Chihara, Site 102
Contact
Renovatio Clinical (Millennium Physicians Woodlands)
The Woodlands Texas, 77380, United States More Info
Jonathan Lu, Site 103
Contact
Renovatio Clinical (Millennium Physicians Woodlands)
The Woodlands Texas, 77389, United States
Texas Oncology, P.A. - Tyler
Tyler Texas, 75702, United States
Benaroya Research Institute At Virginia Mason
Seattle Washington, 98101, United States More Info
David Aboulafia, Site 150
Contact
206-223-6193
MultiCare Institute for Research and Innovation
Tacoma Washington, 98405, United States

How clear is this clinincal trial information?

Study is for people with:

Non Hodgkin Lymphoma

Estimated Enrollment:

1000

Study ID:

NCT04982471

Recruitment Status:

Recruiting

Sponsor:


Celgene

How clear is this clinincal trial information?

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