Donor T Cells After Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies

Inclusion Criteria:

INCLUSION CRITERIA PRIOR TO TRANSPLANT:
The clinical trial will be offered to all high risk (defined 3 below) patients with hematologic malignancies who require stem cell transplants as part of their standard of care using matched related or unrelated donors

Patients with high risk myeloid or lymphoid malignancies at stem cell transplant following American Society for Blood and Marrow Transplantation (ASBMT) criteria, including but not limited to conditions listed; these criteria apply BEFORE cyto-reductive therapy given within 28 days of planned conditioning:

Refractory acute myelogenous or lymphoid leukemia
Relapsed acute myelogenous or lymphoid leukemia
Myelodysplastic syndromes with 5% or more blasts
Chronic myelogenous leukemia in chronic phase 3 or more, blast phase presently, or second accelerated phase
Recurrent or refractory malignant lymphoma or Hodgkin's disease with less than a partial response at transplant
High risk chronic lymphocytic leukemia defined as no response or stable disease to the most recent treatment regimen
DONORS: Matched related or unrelated donor stem cell transplant (SCT) matched at human leukocyte antigen (HLA) A- B, C, and DRB1 by molecular methods; 7 of 8 matched donor acceptable for related donors
T-cell depletion with anti-thymocyte globulin (ATG) (rabbit or horse) or at least 30 mg of alemtuzumab total in the conditioning regimen
Immune suppression; planned post-transplant immune suppression should include tacrolimus or cyclosporin monotherapy (i.e., calcineurin inhibitor or CN) for alemtuzumab regimens and a second immune suppressant for ATG treated patients; other agents may be used if CN intolerance or toxicity occurs post-transplant
Zubrod performance status (PS) 0-2 or equivalent Karnofsky PS
Eligible for allogeneic transplant in the treating physicians' judgment and by institutional standards
ELIGIBILITY TO RECEIVE DLI POST-TRANSPLANT:
Donor lymphocytes available or able to be collected
No evidence of disease by standard morphology; minimal residual disease or molecular evidence of disease will not exclude
Absolute neutrophil count >= 500/μl
Platelet count >= 20,000/μl without transfusion for 7 days
Serum glutamic oxaloacetic transaminase (SGOT) and serum glutamate pyruvate transaminase (SGPT) =< 5 x upper limit of normal (ULN)
Bilirubin =< 3 x ULN
No evidence of grade II or higher acute GVHD or chronic GVHD at initiation of first DLI
No systemic corticosteroids or immunosuppressive drugs (topical acceptable); replacement steroids for adrenal insufficiency are not excluded

Exclusion Criteria:

EXCLUSION CRITERIA PRIOR TO TRANSPLANT:
Pregnant or lactating females
Hepatitis B with positive viral load prior to transplant conditioning or hepatitis C virus
Human immune deficiency virus
Psychiatric illness that may make compliance to the clinical protocol unmanageable or may compromise the ability of the patient to give informed consent
Creatinine >= 2.0 mg/dL
SGOT and SGPT >= 5 x ULN; liver biopsy preferred for such patients
Bilirubin >= 3 x ULN (unless Gilbert's syndrome)
Diffusing capacity of the lung for carbon monoxide (DLCO) < 50% corrected for hemoglobin
Left ventricular ejection fraction or shortening fraction < 40%
Unlikely to be able to procure additional donor lymphocytes