Efficacy Study of T Cell Depleted Allogeneic Non-myeloablative Stem Cell Transplant

Recipient Inclusion Criteria:

Subjects must have their diagnosis confirmed at the transplant center.
Performance status must be Cancer and Leukemia Group B (CALGB) = 0, 1, or 2.
Subjects must have a 3-6/6 human leukocyte antigen (HLA)-matched related donor or 8/8 or better allele level match matched unrelated donor (MUD) (at A,B, C, DRB1, DQ).
HIV negative.
Women of child bearing potential must have a negative pregnancy test within 1 week of starting therapy.
Subjects > or equal to 18 years of age are eligible.
Subjects must have a Multi Gated Acquisition Scan (MUGA) and/or Echocardiography (ECHO) or cardiac magnetic resonance (MR) and or diffusing capacity testing of the lung for carbon monoxide (DLCO) performed before transplant.

Specific populations:

Group A) Subjects with a high chance of progressive lymphoid or myelomatous diseases.
Group B) Subjects with a high chance of progressive myeloid diseases, marrow failure syndromes or myeloproliferative disorders

Recipient Exclusion Criteria:

Pregnant or lactating women.
Subjects with other major medical or psychiatric illnesses which the treating physician feels could seriously compromise tolerance to this protocol.
Subjects with uncontrolled, progressive infections.
Subjects who are good candidates for long term disease control with standard chemotherapy or radiation or high dose therapy and autologous support.
Subjects with active central nervous system (CNS) disease.

Donor Inclusion Criteria:

Donor must be capable of providing informed consent. If 14-17 years of age, a 'single patient exemption' from the local Institutional Review Board must be obtained.

Donor must not have any medical condition which would make mobilization or apheresis more than a minimal risk, and should have the following:

Adequate cardiac function by history and physical examination. Those with a history of cardiac failure or infarction should be evaluated by a cardiologist prior to donation
Adequate hematopoietic function with hematocrit ≥ 30%, white blood cell count of 3000, and platelets 100,000.
Females should not be pregnant or lactating and have a negative serum pregnancy test within 1 week of beginning mobilization if of child bearing potential.