Fludarabine and Total-Body Irradiation Followed By Donor Stem Cell Transplant and Cyclosporine and Mycophenolate Mofetil in Treating HIV-Positive Patients With or Without Cancer

Inclusion Criteria:

Patients with hematologic malignancy, lymphoma or other HIV-associated malignancy are eligible provided these criteria are met:

The malignancy is in complete remission or very good partial remission, defined as a significant reduction of disease with therapy and no evidence for continued tumor growth in the case of lymphoma or solid tumors
Highly active antiretroviral therapy (HAART) is initiated within one month of hematopoietic cell transplant
Viral load has decreased by >= 1.5 logs or viral load < 5000 copies/ml plasma on HAART therapy
CD4 count is allowed to be > 100 cells/ul

HIV infected patients without malignancy who have failed HAART are eligible provided that these criteria are met:

They have been treated with more than one regimen of HAART for a total of at least 6 months duration
The viral load is < 50 copies/ml plasma
The CD4 count < 100 cells/ul

DONOR: Human leukocyte antigen (HLA) genotypically/phenotypically identical donor; if more than one HLA-identical sibling is available, priority will be given to donors matched for cytomegalovirus (CMV) status, ABO titer, and sex

Peripheral blood stem cells will be collected from donors greater than 12 years of age
Bone marrow will be collected from donors less than 12 years of age

DONOR: HLA phenotypically identical unrelated donor; match grades allowed:

Match grade 1: Matched at allele level for HLA-A, B, C, DRB1, and DQB1
Match grade 2.1: Single allele disparity for HLA-A, B, C, DRB1, and DQB1

Exclusion Criteria:

Positive serology for toxoplasma gondii on treatment or with evidence of active infection
Patients with other disease or organ dysfunction that would limit survival to less than 30 days
Patients with medical history of noncompliance with HAART or medical therapy
DONOR: Donors for whom medical or psychologic reasons would make donor procedure intolerable
DONOR: Marrow donors who have increased anesthetic risk
DONOR: Donors who are HIV positive
DONOR: Age > 75 years