MP470 in Treating Patients With Unresectable or Metastatic Solid Tumor or Lymphoma

DISEASE CHARACTERISTICS:

Inclusion criteria:

Histological or cytological diagnosis of unresectable or metastatic solid-tumor cancer that is refractory to standard therapies OR for which no standard therapy exists

Patients with refractory lymphoma (Hodgkin or non-Hodgkin) are also permitted to participate

Exclusion criteria:

Active CNS metastases (primary brain tumors are permitted)

PATIENT CHARACTERISTICS:

Inclusion criteria:

Karnofsky performance status ≥ 70%
Hemoglobin ≥ 9 g/dL
ANC ≥ 1.5 × 10^9/L
Platelet count ≥ 100 × 10^9/L
Total serum bilirubin ≤ 2 mg/dL
AST and ALT ≤ 2.5 × ULN (upper limit of normal for the clinical laboratory), but ≤ 5 × ULN is acceptable if due to hepatic metastases
Serum albumin ≥ 2 g/dL
Serum creatinine ≤ 2 mg/dL
LVEF ≥ 50% on ECHO
No significant abnormalities on the screening ECG (e.g., left bundle branch block, 3rd degree AV block, acute myocardial infarction or QTc interval > 450 msec)
No history of additional risk factors for torsade de pointes (e.g., heart failure, hypokalemia or family history of Long QT Syndrome)
Able to swallow MP470 capsules
Capable of fasting for 6 hours
Not pregnant or nursing
Negative pregnancy test
Fertile patients must use effective contraception during and for 3 months following completion of study treatment

Exclusion criteria:

Life-threatening illness, medical condition, or organ system dysfunction which, in the investigator's opinion, could compromise the patient's safety, interfere with the absorption or metabolism of oral MP470, or put the study outcomes at risk
Any serious, uncontrolled active infection that requires systemic treatment
History of significant cardiovascular disease such as uncontrolled or symptomatic arrhythmias, congestive heart failure, and/or myocardial infarction

PRIOR CONCURRENT THERAPY:

Inclusion criteria:

Recuperated from any prior surgical procedures including at least 4 weeks rest since a major surgery

Exclusion criteria:

Patient has received any anticancer agent(s) within the past 3 weeks, including investigational agents, chemotherapy (6 weeks for nitrosoureas or mitomycin), immunotherapy, biologic, or hormonal therapy other than luteinizing hormone-releasing hormone (LHRH) agonists
Patient has received radiation therapy within the past 4 weeks
Patient has a grade 2 or more severe toxicity (other than alopecia) continuing from prior anticancer therapy
Patient requires treatment with immunosuppressive agents other than corticosteroids that have been at stable doses for at least 2 weeks