Obinutuzumab and ICE Chemotherapy in Refractory/Recurrent CD20+ Mature NHL

Inclusion Criteria:

Patients in first relapse or primary induction failure CD20 positive B-cell leukemia/lymphoma including:

Diffuse Large B-Cell Lymphoma
Burkitt Lymphoma
High Grade B-cell Lymphoma: Not Otherwise Specified (NOS)
Primary mediastinal B-cell lymphoma (PMBL)
CD20+ B-lymphoblastic lymphoma
Follicular lymphoma, Grade III
Karnofsky ≥ 60% for patients > 16 years of age and
Lansky ≥ 60 for patients ≤ 16 years of age.
Myelosuppressive chemotherapy: Must not have received within 2 weeks of entry onto this study.
Patients may not have received prior therapy with obinutuzumab (GA101)
Radiation Therapy (XRT): Date of receiving prior XRT must be > 2 weeks for local palliative XRT (small port); > 6 months must have elapsed if prior craniospinal XRT or if > 50% radiation of pelvis; > 6 weeks must have elapsed if other substantial bone marrow radiation.
Steroids: Patients may have received prior steroid treatment, but not started greater than 7 days prior to initiation of protocol therapy.
Adequate organ function.

Exclusion Criteria:

Patients with newly diagnosed, previously untreated B-NHL.
Known congenital or acquired immune deficiency.
Prior solid organ transplantation.
Prior allogeneic stem cell transplant within 60 days or active acute Graft-vs-Host-Disease (GVHD) grade 3 or higher.
History of grade 4 anaphylactic reactions to humanized or murine monoclonal antibodies
Uncontrolled hepatitis B and/or C infection