Panobinostat and Everolimus in Treating Patients With Relapsed or Refractory Lymphoma or Multiple Myeloma

DISEASE CHARACTERISTICS:

Histologically confirmed diagnosis of one of the following:

Hodgkin or non-Hodgkin lymphoma (including small lymphocytic lymphoma [SLL])

Any histology, including B, T, or NK/T cell allowed
Multiple myeloma (MM)

Relapsed or refractory disease

Patients with lymphoma must have relapsed after or be refractory to an upfront regimen (e.g., CHOP or ABVD) and a salvage regimen (e.g., ICE or ESHAP)

Patients with SLL should have relapsed after a fludarabine-containing regimen
Patients with MM must have progressed within 100 days after receiving a regimen containing bortezomib and either thalidomide or lenalidomide AND have a 25% increase in serum paraproteins, urinary light chains, or plasma cell number in the bone marrow
No active CNS disease

PATIENT CHARACTERISTICS:

ECOG performance status 0-2
ANC ≥ 1,500/mm³
Platelet count ≥ 75,000/mm³ (transfusion allowed in patients with biopsy-proven bone marrow involvement)
AST and ALT ≤ 2.5 times upper limit of normal (ULN) (≤ 5.0 times ULN if elevation due to leukemic involvement)
Serum bilirubin ≤ 1.5 times ULN
Serum creatinine ≤ 1.5 times ULN OR creatinine clearance ≥ 50 mL/min
Serum potassium normal
Serum phosphorous normal
Serum total calcium (corrected for serum albumin) or serum ionized calcium normal
Serum magnesium normal
TSH and free T4 normal (thyroid hormone replacement allowed)
Fasting serum cholesterol ≤ 300 mg/dL (or ≤ 7.75 mmol/L) AND fasting triglycerides ≤ 2.5 times ULN (elevated levels allowed provided an appropriate lipid-lowering medication has been initiated)
LVEF normal by MUGA or ECHO
Not pregnant or nursing
Negative pregnancy test
Fertile patients must use effective double-method (including barrier method) contraception during and for 3 months after completion of study treatment

No impaired cardiac function, including any of the following:

QTc > 450 msec by screening ECG
Congenital long QT syndrome
History of sustained ventricular tachycardia
History of ventricular fibrillation or torsades de pointes
Bradycardia, defined as heart rate (HR) < 50 beats/min (pacemaker allowed provided HR ≥ 50 beats/min)
Myocardial infarction or unstable angina within the past 6 months
NYHA class III-IV congestive heart failure
Right bundle branch block and left anterior hemiblock (bifascicular block)
No uncontrolled hypertension
No unresolved diarrhea > CTCAE grade 1
No impairment of gastrointestinal (GI) function or GI disease that may significantly alter the absorption of oral agents (e.g., ulcerative disease, uncontrolled nausea, vomiting, diarrhea, malabsorption syndrome, or small bowel resection)
No other concurrent severe or uncontrolled medical condition
No other primary malignancy within the past 5 years other than curatively treated carcinoma in situ of the cervix or basal cell or squamous cell carcinoma of the skin
No known HIV or hepatitis C positivity
No significant history of non-compliance to medical regimens
No known hypersensitivity to everolimus, other rapamycins (e.g., sirolimus or temsirolimus), or their excipients

PRIOR CONCURRENT THERAPY:

See Disease Characteristics
Prior autologous or allogeneic stem cell transplantation allowed
More than 3 weeks since prior chemotherapy (6 weeks for nitrosoureas or mitomycin C) or radiotherapy and recovered
More than 1 week since prior and no concurrent immunization with live attenuated vaccines
More than 4 weeks since prior valproic acid
No other prior histone deacetylase inhibitors

No concurrent chronic systemic corticosteroids or another immunosuppressive agent, other than for control of itching (as in cutaneous T-cell lymphoma)

Concurrent corticosteroids allowed provided patient has been on a stable dosage regimen for ≥ 2 weeks before study entry
Topical or inhaled corticosteroids allowed
No concurrent drugs that may induce torsades de pointes
No concurrent CYP3A4 inhibitors
No concurrent radiotherapy or other anticancer therapy
No concurrent grapefruit, grapefruit juice, or seville (sour) oranges
No concurrent medications that may cause QTc prolongation
No other concurrent investigational therapy