Phase II Study Evaluating Busulfan and Fludarabine as Preparative Therapy in Adults With Hematopoietic Disorders Undergoing MUD SCT

Inclusion Criteria:

No fully or single-antigen mismatched sibling donor is available to donate stem cells.
Age >15 and <61
ECOG PS < or equal to 2
Adequate renal function with serum creatinine <2.0 mg/dl
Pulmonary diffusing capacity >40% of predicted
Cardiac ejection fraction >40% as measured by radionuclide wall motion study or echocardiography
No active liver disease. Total bilirubin must be < or equal to 2.0 mg/dl. Alkaline phosphatase and AST must be less than three times the upper limit of normal. Patients with hepatitis C and active hepatitis B are eligible only if a liver biopsy is performed and there is < or equal to grade 2 inflammation. Patients wtih a history of HBV infection should be tested for HBeAg, antiHBe and HBV DNA (quantitative). Patients with active HBV viral replication should receive anti-viral therapy.
Negative serology for the human immunodeficiency virus (HIV)
Available HLA-matched donor (see HLA compatibility requirements below)
Signed informed consent from the recipient

Exclusion Criteria:

Ongoing active infection
Pregnancy and/or nursing
Active, uncontrolled CNS leukemia
Opinion of BMT Committee that autologous or mini-allogeneic transplant would be the preferable form of treatment
Receipt of any chemotherapy within 3 weeks of study entry except for hydroxyurea or imatinib mesylate. Use of interferon within 3 months of starting therapy.