Non Hodgkin Lymphoma Clinical Trial

S0016 Combination Chemotherapy With Monoclonal Antibody Therapy in Newly Diagnosed Non-Hodgkin’s Lymphoma

Summary

RATIONALE: Drugs used in chemotherapy work in different ways to stop cancer cells from dividing so they stop growing or die. Monoclonal antibodies can locate tumor cells and either kill them or deliver radioactive tumor-killing substances to them without harming normal cells. It is not yet known which monoclonal antibody plus combination chemotherapy regimen is more effective in treating non-Hodgkin's lymphoma.

PURPOSE: This randomized phase III trial is comparing 2 different monoclonal antibodies given together with combination chemotherapy to see how well they work in treating patients with newly-diagnosed non-Hodgkin's lymphoma.

View Full Description

Full Description

OBJECTIVES:

Compare the progression-free survival and overall survival of patients with newly diagnosed follicular non-Hodgkin's lymphoma treated with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) with or without either rituximab or iodine I 131 tositumomab (monoclonal antibody anti-B1). (CHOP chemotherapy alone arm closed to accrual as of 12/15/02)
Compare the response rate of these patients treated with these regimens.
Compare the toxic effects of these regimens in these patients.
Compare the molecular remission rates of this patient population treated with these regimens.
Determine the incidence and time to development of human anti-mouse antibody positivity.

OUTLINE: This is a randomized, multicenter study. Patients are stratified according to whether microglobulin is greater than upper limit of normal (yes vs no). Patients are randomized to 1 of 3 treatment arms. (Arm I closed to accrual as of 12/15/02)

Arm I (CHOP only): Patients receive cyclophosphamide IV over 15 minutes, doxorubicin IV over 5-20 minutes, and vincristine IV over 5-15 minutes on day 1. Patients also receive oral prednisone daily on days 1-5. Treatment continues every 21 days for up to 6 courses in the absence of disease progression or unacceptable toxicity. (Arm I closed to accrual as of 12/15/02)
Arm II (CHOP + rituximab): Patients receive cyclophosphamide IV over 15 minutes, doxorubicin IV over 5-20 minutes, and vincristine IV over 5-15 minutes on days 8, 29, 50, 71, 92, and 113. Patients also receive oral prednisone daily on days 8-12, 29-33, 50-54, 71-75, and 113-117 and rituximab IV over 4-6 hours on days 1, 6, 48, 90, 134, and 141.
Arm III (CHOP + tositumomab): Patients receive chemotherapy as in arm I and tositumomab (monoclonal antibody anti-B1) IV over 1 hour followed by iodine I 131 tositumomab IV over 20 minutes on days 134 and 141.

Patients are followed on day 200, at 1 year, every 6 months for 2 years, and then annually thereafter.

PROJECTED ACCRUAL: Approximately 500 patients (250 per treatment arm) will be accrued for this study within 5.5 years. (Arm I closed to accrual as of 12/15/02)

View Eligibility Criteria

Eligibility Criteria

DISEASE CHARACTERISTICS:

Histologically confirmed previously untreated bulky stage II or stage III or IV follicular non-Hodgkin's lymphoma

Grade I-III disease
Cluster of differentiation antigen 20 (CD20) antigen positive
Fewer than 5,000/mm^3 circulating lymphoid cells on a white blood cell (WBC) differential count
Bidimensionally measurable disease
Bone marrow aspiration and biopsy within the past 42 days
No clinical evidence of central nervous system (CNS) involvement by lymphoma

PATIENT CHARACTERISTICS:

Age:

18 and over

Performance status:

Zubrod 0-2

Life expectancy:

Not specified

Hematopoietic:

See Disease Characteristics
Granulocyte count greater than 1,500/mm^3
Platelet count greater than 100,000/mm^3

Hepatic:

Not specified

Renal:

Not specified

Cardiovascular:

No impaired cardiac status, including:

Severe coronary artery disease
Cardiomyopathy
Congestive heart failure
Serious arrhythmia
Ejection fraction at least lower limit of normal by Multi Gated Acquisition Scan (MUGA) or 2-D echocardiogram for questionable cardiac history

Other:

No hypersensitivity to iodine
Not pregnant or nursing
Fertile patients must use effective contraception during and for 6 months after study participation
HIV negative
No other malignancy within the past 5 years except adequately treated basal cell or squamous cell skin cancer or carcinoma in situ of the cervix

PRIOR CONCURRENT THERAPY:

Biologic therapy:

No prior monoclonal antibodies for cancer

Chemotherapy:

No prior chemotherapy for lymphoma

Prior prednisone for non-lymphoma related illnesses allowed

Endocrine therapy:

Not specified

Radiotherapy:

No prior radiotherapy for lymphoma

Surgery:

See Disease Characteristics

Study is for people with:

Non Hodgkin Lymphoma

Phase:

Phase 3

Estimated Enrollment:

571

Study ID:

NCT00006721

Recruitment Status:

Active, not recruiting

Sponsor:

Southwest Oncology Group

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There are 218 Locations for this study

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Alaska Regional Hospital Cancer Center
Anchorage Alaska, 99508, United States
Fairbanks Cancer Treatment Center at Fairbanks Memorial Hospital
Fairbanks Alaska, 99701, United States
Hembree Mercy Cancer Center at St. Edward Mercy Medical Center
Fort Smith Arkansas, 72903, United States
Arkansas Cancer Research Center at University of Arkansas for Medical Sciences
Little Rock Arkansas, 72205, United States
Alta Bates Summit Comprehensive Cancer Center
Berkeley California, 94704, United States
Peninsula Medical Center
Burlingame California, 94010, United States
Marin Cancer Institute at Marin General Hospital
Greenbrae California, 94904, United States
Sutter Health - Western Division Cancer Research Group
Greenbrae California, 94904, United States
Desert Regional Medical Center Comprehensive Cancer Center
Palm Springs California, 92262, United States
University of California Davis Cancer Center
Sacramento California, 95817, United States
California Pacific Medical Center - California Campus
San Francisco California, 94118, United States
Stanford Cancer Center
Stanford California, 94305, United States
Sutter Solano Medical Center
Vallejo California, 94589, United States
Helen and Harry Gray Cancer Center at Hartford Hospital
Hartford Connecticut, 06102, United States
Lombardi Comprehensive Cancer Center at Georgetown University Medical Center
Washington District of Columbia, 20007, United States
Center for Cancer Care and Research at Watson Clinic, LLP
Lakeland Florida, 33805, United States
Sacred Heart Cancer Center at Sacred Heart Hospital
Pensacola Florida, 32504, United States
West Florida Cancer Institute at West Florida Hospital - Pensacola
Pensacola Florida, 32514, United States
Piedmont Hospital
Atlanta Georgia, 30309, United States
Northside Hospital Cancer Center
Atlanta Georgia, 30342, United States
Saint Joseph's Hospital of Atlanta
Atlanta Georgia, 30342, United States
CCOP - Atlanta Regional
Atlanta Georgia, 30342, United States
WellStar Cobb Hospital
Austell Georgia, 30106, United States
Charles B. Eberhart Cancer Center at DeKalb Medical Center
Decatur Georgia, 30033, United States
Dwight David Eisenhower Army Medical Center
Fort Gordon Georgia, 30905, United States
Northeast Georgia Medical Center
Gainesville Georgia, 30501, United States
Gwinnett Medical Center
Lawrenceville Georgia, 30045, United States
Kennestone Cancer Center at Wellstar Kennestone Hospital
Marietta Georgia, 30060, United States
Southern Regional Medical Center
Riverdale Georgia, 30274, United States
Pearlman Comprehensive Cancer Center at South Georgia Medical Center
Valdosta Georgia, 31603, United States
Tripler Army Medical Center
Honolulu Hawaii, 96859, United States
Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center
Boise Idaho, 83706, United States
Mountain States Tumor Institute at St. Luke's Regional Medical Center
Boise Idaho, 83712, United States
Saint Anthony's Hospital at Saint Anthony's Health Center
Alton Illinois, 62002, United States
Rush-Copley Cancer Care Center
Aurora Illinois, 60504, United States
St. Joseph Medical Center
Bloomington Illinois, 61701, United States
Graham Hospital
Canton Illinois, 61520, United States
Memorial Hospital
Carthage Illinois, 62321, United States
University of Illinois Cancer Center
Chicago Illinois, 60612, United States
University of Chicago Cancer Research Center
Chicago Illinois, 60637, United States
Decatur Memorial Hospital Cancer Care Institute
Decatur Illinois, 62526, United States
Eureka Community Hospital
Eureka Illinois, 61530, United States
Galesburg Clinic, PC
Galesburg Illinois, 61401, United States
Galesburg Cottage Hospital
Galesburg Illinois, 61401, United States
Mason District Hospital
Havana Illinois, 62644, United States
Veterans Affairs Medical Center - Hines
Hines Illinois, 60141, United States
Hopedale Medical Complex
Hopedale Illinois, 61747, United States
Joliet Oncology-Hematology Associates, Limited - West
Joliet Illinois, 60435, United States
McDonough District Hospital
Macomb Illinois, 61455, United States
Cardinal Bernardin Cancer Center at Loyola University Medical Center
Maywood Illinois, 60153, United States
Good Samaritan Regional Health Center
Mount Vernon Illinois, 62864, United States
Edward Hospital Cancer Center
Naperville Illinois, 60540, United States
BroMenn Regional Medical Center
Normal Illinois, 61761, United States
Community Cancer Center
Normal Illinois, 61761, United States
Community Hospital of Ottawa
Ottawa Illinois, 61350, United States
Oncology Hematology Associates of Central Illinois, PC - Ottawa
Ottawa Illinois, 61350, United States
Cancer Treatment Center at Pekin Hospital
Pekin Illinois, 61554, United States
Proctor Hospital
Peoria Illinois, 61614, United States
CCOP - Illinois Oncology Research Association
Peoria Illinois, 61615, United States
Oncology Hematology Associates of Central Illinois, PC - Peoria
Peoria Illinois, 61615, United States
Methodist Medical Center of Illinois
Peoria Illinois, 61636, United States
OSF St. Francis Medical Center
Peoria Illinois, 61637, United States
Illinois Valley Community Hospital
Peru Illinois, 61354, United States
Perry Memorial Hospital
Princeton Illinois, 61356, United States
St. Margaret's Hospital
Spring Valley Illinois, 61362, United States
Regional Cancer Center at Memorial Medical Center
Springfield Illinois, 62781, United States
Carle Cancer Center at Carle Foundation Hospital
Urbana Illinois, 61801, United States
CCOP - Carle Cancer Center
Urbana Illinois, 61801, United States
St. Francis Hospital and Health Centers - Beech Grove Campus
Beech Grove Indiana, 46107, United States
Elkhart General Hospital
Elkhart Indiana, 46515, United States
Howard Community Hospital
Kokomo Indiana, 46904, United States
Center for Cancer Therapy at LaPorte Hospital and Health Services
La Porte Indiana, 46350, United States
Saint Anthony Memorial Health Centers
Michigan City Indiana, 46360, United States
Reid Hospital & Health Care Services
Richmond Indiana, 47374, United States
CCOP - Northern Indiana CR Consortium
South Bend Indiana, 46601, United States
Memorial Hospital of South Bend
South Bend Indiana, 46601, United States
Saint Joseph Regional Medical Center
South Bend Indiana, 46617, United States
Siouxland Hematology-Oncology Associates, LLP
Sioux City Iowa, 51101, United States
Mercy Medical Center - Sioux City
Sioux City Iowa, 51104, United States
St. Luke's Regional Medical Center
Sioux City Iowa, 51104, United States
Cancer Center of Kansas, PA - Chanute
Chanute Kansas, 66720, United States
Cancer Center of Kansas, PA - Dodge City
Dodge City Kansas, 67801, United States
Cancer Center of Kansas, PA - El Dorado
El Dorado Kansas, 67042, United States
Cancer Center of Kansas-Independence
Independence Kansas, 67301, United States
Providence Medical Center
Kansas City Kansas, 66112, United States
Cancer Center of Kansas, PA - Kingman
Kingman Kansas, 67068, United States
Lawrence Memorial Hospital
Lawrence Kansas, 66044, United States
Southwest Medical Center
Liberal Kansas, 67901, United States
Cancer Center of Kansas, PA - Newton
Newton Kansas, 67114, United States
Menorah Medical Center
Overland Park Kansas, 66209, United States
Johnson County Radiation Therapy
Overland Park Kansas, 66210, United States
Cancer Center of Kansas, PA - Parsons
Parsons Kansas, 67357, United States
Cancer Center of Kansas, PA - Pratt
Pratt Kansas, 67124, United States
Cancer Center of Kansas, PA - Salina
Salina Kansas, 67042, United States
Tammy Walker Cancer Center at Salina Regional Health Center
Salina Kansas, 67401, United States
Shawnee Mission Medical Center
Shawnee Mission Kansas, 66204, United States
Cotton-O'Neil Cancer Center
Topeka Kansas, 66606, United States
Cancer Center of Kansas, PA - Wellington
Wellington Kansas, 67152, United States
Associates in Womens Health, PA - North Review
Wichita Kansas, 67208, United States
Cancer Center of Kansas, PA - Medical Arts Tower
Wichita Kansas, 67208, United States
Cancer Center of Kansas, PA - Wichita
Wichita Kansas, 67214, United States
CCOP - Wichita
Wichita Kansas, 67214, United States
Via Christi Cancer Center at Via Christi Regional Medical Center
Wichita Kansas, 67214, United States
Wesley Medical Center
Wichita Kansas, 67214, United States
Cancer Center of Kansas, PA - Winfield
Winfield Kansas, 67156, United States
Greenebaum Cancer Center at University of Maryland Medical Center
Baltimore Maryland, 21201, United States
Alvin and Lois Lapidus Cancer Institute at Sinai Hospital
Baltimore Maryland, 21215, United States
Lahey Clinic Medical Center - Burlington
Burlington Massachusetts, 01805, United States
Berkshire Hematology Oncology, PC
Pittsfield Massachusetts, 01201, United States
University of Michigan Comprehensive Cancer Center
Ann Arbor Michigan, 48109, United States
Battle Creek Health System Cancer Care Center
Battle Creek Michigan, 49017, United States
Bay Regional Medical Center
Bay City Michigan, 48708, United States
Mecosta County Medical Center
Big Rapids Michigan, 49307, United States
Barbara Ann Karmanos Cancer Institute
Detroit Michigan, 48201, United States
Josephine Ford Cancer Center at Henry Ford Hospital
Detroit Michigan, 48202, United States
Butterworth Hospital at Spectrum Health
Grand Rapids Michigan, 49503, United States
CCOP - Grand Rapids
Grand Rapids Michigan, 49503, United States
Lacks Cancer Center at Saint Mary's Health Care
Grand Rapids Michigan, 49503, United States
Holland Community Hospital
Holland Michigan, 49423, United States
Borgess Medical Center
Kalamazoo Michigan, 49001, United States
West Michigan Cancer Center
Kalamazoo Michigan, 49007, United States
Bronson Methodist Hospital
Kalamazoo Michigan, 49007, United States
Hackley Hospital
Muskegon Michigan, 49442, United States
Lakeland Regional Cancer Care Center - St. Joseph
Saint Joseph Michigan, 49085, United States
Oncology Care Associates, PLLC
Saint Joseph Michigan, 49085, United States
Munson Medical Center
Traverse City Michigan, 49684, United States
Metro Health Hospital
Wyoming Michigan, 49519, United States
University of Mississippi Cancer Clinic
Jackson Mississippi, 39216, United States
Southeast Missouri Regional Cancer Center at Southeast Missouri Hospital
Cape Girardeau Missouri, 63701, United States
Saint Francis Medical Center
Cape Girardeau Missouri, 63703, United States
Saint Luke's Hospital
Chesterfield Missouri, 63017, United States
Veterans Affairs Medical Center - Columbia (Truman Memorial)
Columbia Missouri, 65201, United States
Ellis Fischel Cancer Center at University of Missouri - Columbia
Columbia Missouri, 65203, United States
Independence Regional Health Center
Independence Missouri, 64050, United States
Freeman Cancer Institute at Freeman Health System
Joplin Missouri, 64804, United States
St. John's Regional Medical Center
Joplin Missouri, 64804, United States
Truman Medical Center - Hospital Hill
Kansas City Missouri, 64108, United States
Saint Luke's Cancer Institute at Saint Luke's Hospital
Kansas City Missouri, 64111, United States
Kansas City Cancer Center at St. Joseph's Medical Mall
Kansas City Missouri, 64114, United States
St. Joseph Medical Center
Kansas City Missouri, 64114, United States
North Kansas City Hospital
Kansas City Missouri, 64116, United States
Parvin Radiation Oncology
Kansas City Missouri, 64116, United States
CCOP - Kansas City
Kansas City Missouri, 64131, United States
Radiation Oncology Associates of Kansas City at Northland Radiation Oncology Center
Kansas City Missouri, 64154, United States
Heartland Regional Medical Center
Saint Joseph Missouri, 64506, United States
Midwest Hematology Oncology Group, Incorporated
Saint Louis Missouri, 63109, United States
Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis
Saint Louis Missouri, 63110, United States
CCOP - St. Louis-Cape Girardeau
Saint Louis Missouri, 63141, United States
David C. Pratt Cancer Center at St. John's Mercy
Saint Louis Missouri, 63141, United States
CCOP - Cancer Research for the Ozarks
Springfield Missouri, 65802, United States
St. John's Regional Health Center
Springfield Missouri, 65804, United States
Hulston Cancer Center at Cox Medical Center South
Springfield Missouri, 65807, United States
CCOP - Montana Cancer Consortium
Billings Montana, 59101, United States
Hematology-Oncology Centers of the Northern Rockies - Billings
Billings Montana, 59101, United States
Northern Rockies Radiation Oncology Center
Billings Montana, 59101, United States
St. Vincent Healthcare Cancer Care Services
Billings Montana, 59101, United States
Billings Clinic - Downtown
Billings Montana, 59107, United States
Bozeman Deaconess Cancer Center
Bozeman Montana, 59715, United States
St. James Healthcare Cancer Care
Butte Montana, 59701, United States
Big Sky Oncology
Great Falls Montana, 59405, United States
Great Falls Clinic - Main Facility
Great Falls Montana, 59405, United States
Sletten Cancer Institute at Benefis Healthcare
Great Falls Montana, 59405, United States

Great Falls Montana, 59405, United States
St. Peter's Hospital
Helena Montana, 59601, United States
Glacier Oncology, PLLC
Kalispell Montana, 59901, United States
Kalispell Medical Oncology at KRMC
Kalispell Montana, 59901, United States
Kalispell Regional Medical Center
Kalispell Montana, 59901, United States
Community Medical Center
Missoula Montana, 59801, United States
Guardian Oncology and Center for Wellness
Missoula Montana, 59804, United States
Montana Cancer Specialists at Montana Cancer Center
Missoula Montana, 59807, United States
Montana Cancer Center at St. Patrick Hospital and Health Sciences Center
Missoula Montana, 59807, United States
Good Samaritan Cancer Center at Good Samaritan Hospital
Kearney Nebraska, 68848, United States
UNMC Eppley Cancer Center at the University of Nebraska Medical Center
Omaha Nebraska, 68198, United States
Roswell Park Cancer Institute
Buffalo New York, 14263, United States
Tucker Center for Cancer Care at Orange Regional Medical Center
Middletown New York, 10940, United States
New York Weill Cornell Cancer Center at Cornell University
New York New York, 10021, United States
James P. Wilmot Cancer Center at University of Rochester Medical Center
Rochester New York, 14642, United States
Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill
Chapel Hill North Carolina, 27599, United States
Duke Comprehensive Cancer Center
Durham North Carolina, 27710, United States
Wayne Memorial Hospital, Incorporated
Goldsboro North Carolina, 27534, United States
McDowell Cancer Center at Akron General Medical Center
Akron Ohio, 44307, United States
Mary Rutan Hospital
Bellefontaine Ohio, 43311, United States
Adena Regional Medical Center
Chillicothe Ohio, 45601, United States
Good Samaritan Hospital Cancer Treatment Center
Cincinnati Ohio, 45220, United States
Charles M. Barrett Cancer Center at University Hospital
Cincinnati Ohio, 45267, United States
Cleveland Clinic Cancer Center at Fairview Hospital
Cleveland Ohio, 44111, United States
Cleveland Clinic Taussig Cancer Center
Cleveland Ohio, 44195, United States
Riverside Methodist Hospital Cancer Care
Columbus Ohio, 43214, United States
CCOP - Columbus
Columbus Ohio, 43215, United States
Grant Medical Center Cancer Care
Columbus Ohio, 43215, United States
Mount Carmel Health - West Hospital
Columbus Ohio, 43222, United States
Doctors Hospital at Ohio Health
Columbus Ohio, 43228, United States
Grandview Hospital
Dayton Ohio, 45405, United States
Good Samaritan Hospital
Dayton Ohio, 45406, United States
David L. Rike Cancer Center at Miami Valley Hospital
Dayton Ohio, 45409, United States
Samaritan North Cancer Care Center
Dayton Ohio, 45415, United States
Veterans Affairs Medical Center - Dayton
Dayton Ohio, 45428, United States
CCOP - Dayton
Dayton Ohio, 45429, United States
Grady Memorial Hospital
Delaware Ohio, 43015, United States
Blanchard Valley Medical Associates
Findlay Ohio, 45840, United States
Middletown Regional Hospital
Franklin Ohio, 45005, United States
Community Oncology Group at Cleveland Clinic Cancer Center
Independence Ohio, 44131, United States
Charles F. Kettering Memorial Hospital
Kettering Ohio, 45429, United States
Fairfield Medical Center
Lancaster Ohio, 43130, United States
St. Rita's Medical Center
Lima Ohio, 45801, United States
Strecker Cancer Center at Marietta Memorial Hospital
Marietta Ohio, 45750, United States
Licking Memorial Cancer Care Program at Licking Memorial Hospital
Newark Ohio, 43055, United States
Mercy Medical Center
Springfield Ohio, 45504, United States
Community Hospital of Springfield and Clark County
Springfield Ohio, 45505, United States
UVMC Cancer Care Center at Upper Valley Medical Center
Troy Ohio, 45373, United States
Mount Carmel St. Ann's Cancer Center
Westerville Ohio, 43081, United States
Clinton Memorial Hospital
Wilmington Ohio, 45177, United States
Cleveland Clinic - Wooster
Wooster Ohio, 44691, United States
Ruth G. McMillan Cancer Center at Greene Memorial Hospital
Xenia Ohio, 45385, United States
Genesis - Good Samaritan Hospital
Zanesville Ohio, 43701, United States
Legacy Mount Hood Medical Center
Gresham Oregon, 97030, United States
Providence Milwaukie Hospital
Milwaukie Oregon, 97222, United States
Legacy Good Samaritan Hospital & Comprehensive Cancer Center
Portland Oregon, 97210, United States
Providence Cancer Center at Providence Portland Medical Center
Portland Oregon, 97213, United States
Adventist Medical Center
Portland Oregon, 97216, United States
CCOP - Columbia River Oncology Program
Portland Oregon, 97225, United States
Providence St. Vincent Medical Center
Portland Oregon, 97225, United States
Legacy Emanuel Hospital and Health Center and Children's Hospital
Portland Oregon, 97227, United States
Legacy Meridian Park Hospital
Tualatin Oregon, 97062, United States
Roper St. Francis Cancer Center at Roper Hospital
Charleston South Carolina, 29401, United States
Hollings Cancer Center at Medical University of South Carolina
Charleston South Carolina, 29425, United States
Palmetto Health South Carolina Cancer Center
Columbia South Carolina, 29203, United States
CCOP - Greenville
Greenville South Carolina, 29615, United States
Joe Arrington Cancer Research and Treatment Center
Lubbock Texas, 79410, United States
UMC Southwest Cancer and Research Center
Lubbock Texas, 79415, United States
Huntsman Cancer Institute at University of Utah
Salt Lake City Utah, 84112, United States
Lynchburg Hematology-Oncology Clinic
Lynchburg Virginia, 24501, United States
St. Joseph Cancer Center
Bellingham Washington, 98225, United States
Olympic Hematology and Oncology
Bremerton Washington, 98310, United States
St. Francis Hospital
Federal Way Washington, 98003, United States
Columbia Basin Hematology
Kennewick Washington, 99336, United States
Cascade Cancer Center at Evergreen Hospital Medical Center
Kirkland Washington, 98033, United States
Olympic Medical Center
Port Angeles Washington, 98362, United States
Good Samaritan Cancer Center
Puyallup Washington, 98372, United States
Valley Medical Center
Renton Washington, 98055, United States
CCOP - Virginia Mason Research Center
Seattle Washington, 98101, United States
Fred Hutchinson Cancer Research Center
Seattle Washington, 98104, United States
Harborview Medical Center
Seattle Washington, 98104, United States
Minor and James Medical, PLLC
Seattle Washington, 98104, United States
Group Health Central Hospital
Seattle Washington, 98112, United States
Swedish Cancer Institute at Swedish Medical Center - First Hill Campus
Seattle Washington, 98122, United States
Polyclinic First Hill
Seattle Washington, 98122, United States
University Cancer Center at University of Washington Medical Center
Seattle Washington, 98195, United States
Cancer Care Northwest - Spokane South
Spokane Washington, 99202, United States
Franciscan Cancer Center at St. Joseph Medical Center
Tacoma Washington, 98405, United States
Allenmore Hospital
Tacoma Washington, 98405, United States
CCOP - Northwest
Tacoma Washington, 98405, United States
MultiCare Regional Cancer Center at Tacoma General Hospital
Tacoma Washington, 98405, United States
St. Clare Hospital
Tacoma Washington, 98499, United States
Southwest Washington Medical Center Cancer Center
Vancouver Washington, 98668, United States
Wenatchee Valley Medical Center
Wenatchee Washington, 98801, United States
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
Yakima Washington, 98902, United States
Schiffler Cancer Center at Wheeling Hospital
Wheeling West Virginia, 26003, United States
Welch Cancer Center at Sheridan Memorial Hospital
Sheridan Wyoming, 82801, United States

How clear is this clinincal trial information?

Study is for people with:

Non Hodgkin Lymphoma

Phase:

Phase 3

Estimated Enrollment:

571

Study ID:

NCT00006721

Recruitment Status:

Active, not recruiting

Sponsor:


Southwest Oncology Group

How clear is this clinincal trial information?

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