Structural Imaging and Cognitive Functions in Adult Stem Cell Transplant Recipients Treated With Chemotherapy Alone or in Combination With Radiotherapy

Inclusion Criteria:

Diagnosed with acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), acute undifferentiated or biphenotypic leukemia, myelodysplastic syndrome (MDS), Hodgkin's lymphoma, (HL) or non-Hodgkin's lymphoma (NHL), and in complete remission at the time of enrollment
Are scheduled to undergo conditioning treatment with (1) total body radiation (TBI) and chemotherapy or (2) chemotherapy alone prior to receiving a myeloablative allogeneic HSCT
Between 18 and 70 years of age.
Are English speaking.
Have capacity to give consent.

Healthy Control Inclusion Criteria:

Have no diagnosis of cancer except basal cell carcinoma
Between 18 and 70 years of age.
Are English speaking.
Have capacity to give consent

Exclusion Criteria:

Patients with signs and/or symptoms of central nervous system disease as determined by their physician or by a brain MRI, either at the time of enrollment or during the study period.
With disease progression at the time of enrollment or during the study period
With self-reported Axis I psychiatric disorder (DSM-IV), major affective disorder (untreated), bipolar disorder, schizophrenia
With a history of a neurological disorder, neurodegenerative disease, or traumatic brain injury with loss of consciousness
With standard contraindications to MRI examinations

Healthy Control Exclusion Criteria:

Exposure to chemotherapy or radiation therapy for any medical condition
With self-reported Axis I psychiatric disorder (DSM-IV), major affective disorder (untreated), bipolar disorder, schizophrenia
With a history of neurological disorders, neurodegenerative disease, or traumatic brain injury with loss of consciousness
With standard contraindications to MRI examinations