Tipifarnib in Treating Patients With Relapsed or Refractory Lymphoma

Inclusion Criteria:

Biopsy-proven relapsed or refractory lymphomas; previous biopsies =< 6 months prior to treatment on this protocol will be acceptable as long as there has not been intervening therapy; if the patient has received therapy for non-Hodgkin's disease (NHL) between the time of the last biopsy and this protocol, then a re-biopsy is necessary

STUDY 1: Aggressive lymphomas (permanently closed to accrual 6/28/06):

Transformed lymphomas
Diffuse large B cell lymphoma
Mantle cell lymphoma
Follicular lymphoma grade III STUDY 2: Indolent lymphomas (permanently closed to accrual 9/26/07)
Small lymphocytic lymphoma/chronic lymphocytic leukemia
Follicular lymphoma, grades 1, 2
Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) type
Nodal marginal zone B-cell lymphoma
Splenic marginal zone B-cell lymphoma

STUDY 3: Uncommon lymphomas:

Peripheral T cell lymphoma, unspecified
Anaplastic large cell lymphoma (T and null cell type)
Lymphoplasmacytic lymphoma
Mycosis fungoides/ Sezary syndrome

Relapsed Hodgkin's disease (patients must be previously treated and either have had a transplant or not be eligible for a transplant)

Previously treated (no limitations on the number of prior therapies); patients with aggressive lymphoma (Study 1 - permanently closed to accrual 6/28/06) should have received or be ineligible for potentially curable therapy including stem cell transplant
MEASURABLE DISEASE: Must have at least one lesion that has a single diameter of >= 2 cm or tumor cells in the blood >= 5 x10^9/L
Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0, 1, or 2
Absolute neutrophil count >=1000/mm^3
Platelet count >= 75,000
Hemoglobin >= 9 g/dL
Total bilirubin =< 2 x upper limit of normal (ULN) (if > 2 x ULN direct bilirubin is required and should be =< 1.5 x ULN)
Aspartate aminotransferase (AST) =< 3 x ULN (=< 5 x ULN if liver involvement is present)
Serum creatinine =< 2 x ULN
Expected survival >= 3 months
Capable of understanding the investigational nature, potential risks and benefits of the study and able to provide valid informed consent
Capable of swallowing intact study medication tablets
Capable of following directions regarding taking study medication, or has a daily caregiver who will be responsible for administering study medication

Exclusion Criteria:

Any of the following as this regimen may be harmful to a developing fetus or nursing child:

Pregnant women
Breastfeeding women
Men or women of childbearing potential or their sexual partners who are unwilling to employ adequate contraception (condoms, diaphragm, birth control pills, injections, intrauterine device [IUD], surgical sterilization, subcutaneous implants, or abstinence, etc.)
NOTE: The effects of R115777 on the developing human fetus at the recommended therapeutic dose are unknown
Life-threatening illness (unrelated to tumor)
Ongoing radiation therapy or radiation therapy =< 3 weeks prior to study registration unless the acute side effects associated with such therapy are resolved
Therapy with myelosuppressive chemotherapy, cytotoxic chemotherapy, or biologic therapy =< 3 weeks (6 weeks for nitrosourea or mitomycin C) or corticosteroids =< 2 weeks, prior to starting R11577; patients may be on corticosteroids or tapering off them up until the day they start R11577 as long as it is clear that they are not having a tumor response to the steroids or that the steroids would confuse the interpretation of response to R11577; patients may be receiving stable (not increased within the last month) chronic doses of corticosteroids with a maximum dose of 20 mg of prednisone per day if they are being given for disorders other than lymphoma such as rheumatoid arthritis, polymyalgia rheumatica, adrenal insufficiency, or intractable symptoms of lymphoma
Peripheral neuropathy >= grade 3
Serious non-malignant disease such as active infection or other condition which in the opinion of the investigator would compromise other protocol objectives
Presence of central nervous system (CNS) lymphoma
Other active malignancies
Once a patient begins FTI (tipifarnib) treatment, the addition of other cancer treatment will confound the assessment of efficacy and therefore is not allowed; this restriction precludes the addition of cytotoxic, immunologic agents, radiotherapy, or an increase in corticosteroid dose while the patient is in the treatment phase of this protocol
Known to be human immunodeficiency virus (HIV) positive; HIV testing is not required but should be done if clinically indicated; HIV patients are excluded because of concerns regarding excess risk of complications of immunosuppressive therapy regimens
Known allergy to imidazole drugs such as clotrimazole, ketoconazole, miconazole, econazole, fenticonazole, sulconazole, tioconazole, or terconazole