Total Marrow and Total Lymph Node Irradiation, Fludarabine, and Melphalan Followed By Donor Stem Cell Transplant in Treating Patients With Advanced Hematological Cancer That Has Not Responded to Treatment

DISEASE CHARACTERISTICS:

Histopathologically confirmed diagnosis of 1 of the following:

Acute myeloid leukemia (AML)

Myelodysplastic syndromes

Intermediate- or high-risk disease
Myelofibrosis

Granulocytic sarcoma (chloroma)

With or without bone marrow involvement

Mixed lineage leukemia

Induction therapy must have been directed predominantly against AML
Acute lymphoblastic leukemia
Non-Hodgkin lymphoma
Multiple myeloma

Relapsed or refractory disease with M3 marrow (marrow blasts > 25%), meeting 1 of the following criteria:

Persistent disease after an induction attempt
Persistent initial disease after two induction attempts
Relapse after one re-induction attempt (second relapse)
Persistent disease after first relapse and initial re-induction attempt

Not eligible for myeloablative allogeneic hematopoietic stem cell transplantation due to age (> 50 years), organ insufficiency, or significant comorbidity

Patients 16-50 years of age must meet ≥ 1 of the following criteria:

Ejection fraction 50-60% by MUGA scan and/or echocardiogram
DLCO 50-75% of predicted
Creatinine clearance or GFR 60-80 mL/min
Serum bilirubin ≤ 2.0 mg/dL
SGOT and SGPT 1.5-5 times upper limit of normal
No other medical and/or psychosocial problem that, in the opinion of the primary physician or principal investigator, would place the patient at unacceptable risk from study regimen
No Fanconi anemia
HLA-identical sibling OR matched unrelated donor available

PATIENT CHARACTERISTICS:

Zubrod or Karnofsky performance status 70-100%
Negative pregnancy test
Able to lie supine in a full body cast for 30 minutes
No HIV infection
No evidence of active hepatitis B or C infection
No evidence of cirrhosis
No uncontrolled viral, bacterial, or fungal infection within the past 4 weeks
No radiographic changes indicating pulmonary disease (e.g., pulmonary nodules, infiltrates, or pleural effusion) unless cleared by pulmonary biopsy that shows no evidence of active pulmonary disease
No major medical or psychiatric disorder that would seriously compromise patient tolerance of study regimen

PRIOR CONCURRENT THERAPY:

See Disease Characteristics
No prior radiation therapy