VELCADE®-BEAM and Autologous Hematopoietic Stem Cell Transplantation for Non-Hodgkin’s Lymphoma, or Mantle Cell Lymphoma

Inclusion Criteria:

Persistent, relapsed or refractory indolent non-Hodgkin's lymphoma (Follicular grade I, II, or III), non-Hodgkin's lymphoma, composite lymphomas with ≥ 50% of tumor showing follicular histology, transformed follicular, lymphoplasmacytic, marginal zone lymphoma, small Lymphocytic Lymphoma (including T-cell subtypes), or mantle cell lymphoma that is relapsed, refractory, or in PR1 or CR1 (MCL only for CR1).
Age >19 years.
Signed written informed consent.
Expected survival duration of > six months.
Karnofsky Performance Status > 70.
Eligible patients must have: Liver functions < 3x upper limits of normal (ULN) unless due to disease; ANC > 500 cells/mm3 and Platelet Count > 50 mm3.
Patients > age 60 or with clinical signs of heart disease must have ejection fraction ≥ 45% LVEF.
Patients with clinical signs of pulmonary insufficiency must have DLCO to be measured at > 50% of predicted value.
Able to collect > 1.2 X 106/kg CD34+ cell for transplantation.
No serious disease or condition that, in the opinion of the investigator, would compromise the patient's ability to participate in the study.
Female patients must not be pregnant or lactating.
Male and female patients of reproductive potential must follow accepted birth control measures.

Exclusion Criteria:

Patients who are HIV seropositive
Serum creatinine >2.5mg/dL or calculated creatinine clearance ≤ 50ml/min
Total bilirubin >3 times upper limits of normal (unless due to Gilberts disease or malignancy), ALT and AST >4 times the upper limits of normal
Active infection at the time of transplant
Myocardial infarction within 6 months prior to enrollment or has New York Hospital Association (NYHA) Class III or IV heart failure uncontrolled angina, severe uncontrolled ventricular arrhythmias, or electrocardiographic evidence of acute ischemia or active conduction system abnormalities. Prior to study entry, any ECG abnormality at Screening has to be documented by the investigator as not medically relevant.
Patient has hypersensitivity to bortezomib, boron or mannitol.
Female subject is pregnant or breast-feeding. Confirmation that the subject is not pregnant must be established by a negative serum pregnancy test result obtained during screening. Pregnancy testing is not required for post-menopausal or surgically sterilized women.