Non Hodgkin Lymphoma Clinical Trial

Clinical Trial Finder Non Hodgkin Lymphoma Trials

VELCADE,Rituximab,Cyclophosphamide and Decadron

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Summary

Overall response rate and Time to disease progression using this regimen in patients with low-grade B-Cell Non-Hodgkin's Lymphoma.

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Full Description

This is a phase II open label study that is looking at the VRCD combination regimen in patients with previously untreated low-grade Non-Hodgkin's Lymphoma. Treatment will start by combining oral dexamethasone and cyclophosphamide with intravenous VELCADE, rituximab. Chemotherapy cycles will be given as outlined below every 35-days and will continue until two cycles beyond complete remission (CR), toxicity, patient's withdrawal, disease progression, or a maximum of 8 cycles.

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Eligibility Criteria

Inclusion Criteria:

Small Lymphocytic Lymphoma
Follicular Cell Lymphoma (grades I and II)
Mantle Cell Lymphoma patients that are not considered eligible for high-dose therapy and stem cell transplant
Lymphoplasmacytic lymphoma including Waldenstrom's Macroglobulinemia
Marginal Zone Lymphoma
MALT Lymphoma that has ONLY failed antibiotic therapy or involved field radiation.
Adequate bone marrow function, renal function, and hepatic function as outlined in details below.
ECOG performance status of 0, 1, or 2
Able to read, understand, and sign an IRB approved informed consent

Exclusion Criteria:

Known HIV positive status
Known CNS involvement
Prior therapy for lymphoma EXCLUDING antibiotic treatment for MALT-Type NHL.

Study is for people with:

Non Hodgkin Lymphoma

Phase:

Phase 2

Estimated Enrollment:

12

Study ID:

NCT00413959

Recruitment Status:

Terminated

Sponsor:

Oncology Specialists, S.C.

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There are 2 Locations for this study

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Onocology Specialists, S.C
Niles Illinois, 60714, United States
Oncology Specialists, S.C
Park Ridge Illinois, 60068, United States

How clear is this clinincal trial information?

Study is for people with:

Non Hodgkin Lymphoma

Phase:

Phase 2

Estimated Enrollment:

12

Study ID:

NCT00413959

Recruitment Status:

Terminated

Sponsor:


Oncology Specialists, S.C.

How clear is this clinincal trial information?

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