Ovarian Cancer Clinical Trial
68Ga-PSMA PET in Diagnosing Metastasis in Patients With Ovarian Cancer
Summary
This trial studies how well gallium Ga 68-labeled prostate specific membrane antigen (PSMA)-11 (68Ga-PSMA) positron emission tomography (PET) works in patients with ovarian cancer to detect whether the tumor has spread to other places in the body. 68Ga-PSMA is a radioactive substance that binds to blood vessels around the ovarian cancer and can be imaged using PET. Diagnostic procedures, such as PET, may help find and diagnose find out how far the disease has spread.
Full Description
PRIMARY OBJECTIVES:
I. To determine the feasibility and utility of 68Ga-PSMA PET imaging patients with ovarian cancer.
II. Determine detection sensitivity for nodal metastases for PSMA PET stratified by node size.
SECONDARY OBJECTIVES:
I. To assess the correlation between targeted molecular uptake of 68Ga-PSMA PET and PSMA expression in surgical resection specimens.
EXPLORATORY OBJECTIVES:
I. To explore heterogeneity of 68Ga-PSMA PET uptake in cases of metastatic ovarian cancer.
II. To determine the relationship between 68Ga-PSMA PET uptake, diffusion weighted imaging, and MRI-derived tumor perfusion.
OUTLINE:
Patients receive gallium Ga 68-labeled PSMA-11 intravenously (IV) over 1-2 minutes. After about 60 minutes, patients undergo PET/magnetic resonance imaging (MRI) for approximately over 50-60 minutes. Patients may undergo an optional repeat gallium Ga 68-labeled PSMA-11 PET between 8 and 12 weeks after completion of the first PET/MRI.
After completion of study, patients are followed up at 28 days.
Eligibility Criteria
Inclusion Criteria:
Patients with one of the following, identified on prior imaging (CT, MRI or Ultrasound):
adnexal mass
abdominal or pelvic tumor suspicious for ovarian cancer metastases (either suspected on clinical grounds, or known from prior tissue sampling)
Female,
Age >= 18 years
Creatinine Ability to understand a written informed consent document, and the willingness to sign it
Exclusion Criteria:
Pregnant or breastfeeding women
Patient unlikely to comply with study procedure, restrictions and requirements and judged by the investigator to be unsuitable for study participation.
Check Your Eligibility
Let’s see if you might be eligible for this study.
What is your age and gender ?
There is 1 Location for this study
San Francisco California, 94115, United States
How clear is this clinincal trial information?
Please confirm you are a US based health care provider:
Yes, I am a health care Provider No, I am not a health care providerSign Up Now.
Take Control of Your Disease Journey.
Sign up now for expert patient guides, personalized treatment options, and cutting-edge insights that can help you push for the best care plan.