A Phase 1b Study of OMP-305B83 Plus Paclitaxel in Subjects With Ovarian, Peritoneal or Fallopian Tube Cancer

Inclusion Criteria:

Platinum resistant Grade 2 or 3 ovarian, primary peritoneal or fallopian tube cancer
Measureable disease per response evaluation criteria (RECIST) v1.1
Prior bevacizumab
Age > or = 21 years
Adequate organ and marrow function
For women of childbearing potential and men with partners of childbearing potential, agreement (by patient and/or partner) to use two effective forms of contraception from study entry through at least 6 months after the termination visit.
Ability to understand and the willingness to sign a written informed consent document

Exclusion Criteria:

Treatment with any anti-cancer therapy, including radiotherapy, chemotherapy, biologic therapy. Prior therapy with weekly paclitaxel for recurrent disease, unless administered more than 2 years prior to enrollment, unless part of an upfront treatment strategy.
History of abdominal fistula, gastrointestinal perforation, intra-abdominal abscess, clinical signs or symptoms of gastrointestinaI obstruction or other known clinically signification gastrointestinal disease.
Subjects with brain metastases
Subjects with leptomeningial disease or neoplasms in the last 5 years
Blood pressure >140/80
Significant intercurrent illness that will limit the patient's ability to participate in the study
Subjects with known metastases that are currently involving the lumen of the gastrointestinal tract.
Major surgical procedure, open biopsy, or significant traumatic injury within 28 days prior to enrollment, or anticipation of need for major surgical procedure during the course of the study
Pregnant or nursing women
New York Heart Association Classification II, III, or IV
Inability to comply with study and follow up procedure