Assessing Fertility Potential in Female Cancer Survivors

Inclusion Criteria for cancer survivors:

Previous treatment with chemotherapy and/or radiation therapy for either cancer or another illness.
Age between 11-35 years.
Post-menarchal.
Presence of a uterus and at least one ovary.
Ability and willingness to comply with study protocol.
Have given written informed consent, prior to any study-related procedure, not part of normal medical care, with the understanding that consent may be withdrawn by the patient at any time without prejudice to their future medical care.

Inclusion Criteria for controls:

Healthy females who have never been treated for cancer.
Age between 11-35 and 40-50 years.
Post-menarchal with regular cyclic menses (every 21-35 days)
Presence of a uterus and at least 1 ovary.
Ability and willingness to comply with study protocol.
Have given written informed concent, prior to any study-related procedure, not part of normal medical care, with the understanding that consent may be withdrawn by the patient at any time without prejudice to their future medical care.

Exclusion Criteria:

Current pregnancy.
Use of hormonal contraception or use of hormone replacement therapy within the previous 4 weeks.
Lactation within the previous 3 months.
Chronic illness that would limit ability of participant to comply with study protocol.
Any known medical condition, other than cancer, which in the judgement of the investigator is known to be associated with premature ovarian failure (such as Turner's Syndrome or Fragile X) or ovulatory dysfunction (such as thyroid disease, adrenal dysfunction, Cushing's syndrome, hyperprolactinemia, and polycystic ovarian syndrome).
For controls, a history of infertility.