Ovarian Cancer Clinical Trial

Carboplatin and Paclitaxel or Oxaliplatin and Capecitabine With or Without Bevacizumab as First-Line Therapy in Treating Patients With Newly Diagnosed Stage II-IV or Recurrent Stage I Epithelial Ovarian or Fallopian Tube Cancer

Summary

This randomized phase III trial studies carboplatin given together with paclitaxel with or without bevacizumab to see how well it works compared with oxaliplatin given together with capecitabine with or without bevacizumab as first-line therapy in treating patients with newly diagnosed stage II-IV, or recurrent (has come back) stage I epithelial ovarian or fallopian tube cancer. Drugs used in chemotherapy, such as carboplatin, paclitaxel, oxaliplatin, and capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as bevacizumab, may block tumor growth in different ways by targeting certain cells. It is not yet known which regimen of combination chemotherapy given together with or without bevacizumab is more effective in treating epithelial ovarian cancer or fallopian tube cancer.

View Full Description

Full Description

PRIMARY OBJECTIVES:

I. To determine if capecitabine and oxaliplatin reduces the death rate compared to carboplatin and paclitaxel in women with mucinous adenocarcinoma of the ovary or fallopian tube.

II. To determine if bevacizumab reduces the death rate compared to no bevacizumab in women with mucinous adenocarcinoma of the ovary or fallopian tube.

SECONDARY OBJECTIVES:

I. To determine if capecitabine and oxaliplatin increases the duration of progression-free survival (PFS) compared to carboplatin and paclitaxel in women with mucinous adenocarcinoma of the ovary or fallopian tube.

II. To determine if bevacizumab increases the duration of PFS compared to no bevacizumab in women with mucinous adenocarcinoma of the ovary or fallopian tube.

III. To compare the response rates for capecitabine and oxaliplatin versus carboplatin and paclitaxel in patients with mucinous adenocarcinoma of the ovary or fallopian tube with measurable disease after initial tumor reductive surgery.

IV. To compare the response rates for bevacizumab versus no bevacizumab in patients with mucinous adenocarcinoma of the ovary or fallopian tube with measurable disease after initial tumor reductive surgery.

V. To determine the nature and degree of toxicity of capecitabine and oxaliplatin compared with that of carboplatin and paclitaxel in this cohort of patients.

VI. To determine the nature and degree of toxicity of bevacizumab in this cohort of patients.

VII. To compare capecitabine and oxaliplatin versus carboplatin and paclitaxel with respect to changes in patient reported neurotoxicity.

VIII. To determine the impact on quality of life (QOL, as measured by the Functional Assessment of Cancer Therapy-Ovarian [FACT-O] Trial Outcome Index [TOI]) following treatment with the above regimens.

TERTIARY OBJECTIVES:

I. To collect fixed and/or frozen tissue and whole blood for future research studies.

OUTLINE: Patients are randomized to 1 of 4 treatment arms.

ARM I: Patients receive carboplatin intravenously (IV) over 30-60 minutes on day 1 and paclitaxel IV over 3 hours on day 1. Treatment repeats every 3 weeks for 6 courses in the absence of disease progression or unacceptable toxicity.

ARM II: Patients receive oxaliplatin IV over 2-6 hours on day 1 and capecitabine orally (PO) twice daily (BID) on days 1-14. Treatment repeats every 3 weeks for 6 courses in the absence of disease progression or unacceptable toxicity.

ARM III: Patients receive carboplatin and paclitaxel IV as in arm I and bevacizumab IV over 30-90 minutes on day 1. Treatment repeats every 3 weeks for 6 courses in the absence of disease progression or unacceptable toxicity. Patients then receive bevacizumab IV over 30-90 minutes alone on day 1. Treatment repeats every 3 weeks for 12 courses in the absence of disease progression or unacceptable toxicity.

ARM IV: Patients receive oxaliplatin and capecitabine as in arm II, and bevacizumab as in arm III.

After completion of study treatment, patients are followed up at 4-6 weeks, every 3 months for 2 years, and then every 6 months for 3 years.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Patients with a histologic diagnosis of mucinous adenocarcinoma of the ovary or fallopian tube with either optimal (=< 1 cm residual disease) or suboptimal residual disease following initial surgery; patients may have measurable disease as defined by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 or no measurable disease
All patients must have had appropriate surgery including appendectomy (unless patient has history of prior appendectomy) for ovarian or fallopian tube carcinoma with appropriate tissue available for histologic evaluation to confirm diagnosis and stage
Patients must have stage II-IV disease (new or recurrent-chemonaïve; no brain metastasis) or recurrent stage I disease (chemonaïve)
Newly diagnosed patients must begin protocol therapy within 10 weeks of primary debulking; for stage I recurrent patients (chemonaïve), they should begin protocol therapy within 14 days of randomization
Patients must have a negative colonoscopy within 1 year of enrolling in the study
Absolute neutrophil count (ANC) >= 1,500/mcl
White blood cell (WBC) count >= 3,000/mcl
Platelets >= 100,000/mcl
Hemoglobin (Hgb) >= 10 g/dl (can be post transfusion)
Creatinine less than or equal to 1.5 x institutional upper limit normal (ULN) OR creatinine clearance > 50 cc/min
Bilirubin =< 1.5 x ULN
Serum glutamic oxaloacetic transaminase (SGOT) =< to 2.5 x ULN
Alkaline phosphatase =< to 2.5 x ULN
Neuropathy (sensory and motor) =< Common Terminology Criteria for Adverse Events (CTCAE) grade 1
Urine dipstick for proteinuria < 2+; if urine dipstick is >= 2+, 24 hour urine must demonstrate =< 1 g protein in 24 hours OR patients must have a urine protein-to-creatinine ratio (UPCR) < 1.0 mg/dL
Prothrombin time (PT) =< 1.5 x ULN
Activated prothrombin time (APTT) =< 1.5 x ULN
Patients of childbearing potential must agree to practice an effective form of birth control during study treatment and for six months after completion of treatment
Patients who have met the pre-entry requirements
Patients must have signed an approved informed consent and authorization permitting release of personal health information
Patients with Gynecologic Oncology Group (GOG) performance grade of 0, 1 or 2
Patients with life expectancy > 3 months

Exclusion Criteria:

Patients with known colon cancer or history of colon cancer
Patients with primary peritoneal carcinoma
Patients with a history of other invasive malignancies, with the exception of non-melanoma skin cancer, are excluded if there is any evidence of other malignancy being present within the last 5 years; patients are also excluded if their previous cancer treatment contraindicates this protocol therapy
Patients who have received chemotherapy, radiotherapy or any investigational treatment for a gynecologic cancer (does include breast cancer) or colorectal cancer prior to enrollment
Patients with a major surgical procedure anticipated during the course of the study; this includes but is not limited to: abdominal surgery (laparotomy or laparoscopy) such as colostomy or enterostomy reversal, interval or secondary cytoreductive surgery, or second look surgery; please consult with the study chair prior to patient entry for any questions related to the classification of surgical procedures
Patients may have minor surgical procedures (i.e., mediport insertion) fine needle aspiration or core biopsies as long as it is performed > 7 days prior to the first date of bevacizumab therapy and there is no evidence of wound disruption or impaired healing
Patients with surgery (including open biopsy) within 4 weeks prior to anticipated first dose of bevacizumab (allowing for fact that bevacizumab can be omitted from first cycle of chemotherapy)
Patients with a history of abdominal fistula or perforation within the past 12 months
Patients with a current, serious, non-healing wound, ulcer, or bone fracture; patients with granulating incisions healing by secondary intention with no evidence of fascial dehiscence or infection are eligible but require weekly wound examinations
Patients with known hypersensitivity to Chinese hamster cell products or other recombinant human or humanized antibodies
Patients with mixed epithelial ovarian cancer histology
Patients with tumors of low malignant potential
History or evidence of upon physical examination of central nervous system (CNS) disease, including history of primary brain tumor or any history of brain metastases, or seizures not controlled with standard medical therapy
Uncontrolled hypertension, defined as systolic > 150 mm Hg or diastolic > 100 mm Hg; patients with a history of hypertension are permitted
Myocardial infarction or unstable angina within 12 months of the first date of bevacizumab therapy
New York Heart Association (NYHA) grade II or greater congestive heart failure or serious cardiac arrhythmia requiring medication; women who have received prior treatment with anthracycline (including doxorubicin and/or liposomal doxorubicin) and have an ejection fraction < 50% will be excluded from the study
Grade 1, category 2 or greater, peripheral vascular disease; patient cannot have anything worse than mild, symptomatic claudication with exercise
History of cerebrovascular accident (CVA, stroke), transient ischemic attack (TIA) or subarachnoid hemorrhage within six months of the first date of bevacizumab therapy
History of pulmonary embolism or deep vein thrombosis in the past 6 months
Previous history of malabsorption or other conditions preventing oral treatment
Patients who are pregnant or nursing
Patients with acute hepatitis or active infection that requires parenteral antibiotics
Patients with active bleeding or pathologic conditions that carry a high risk of bleeding such as a known bleeding disorder, coagulopathy or tumor involving the major vessels
Patients taking warfarin

Study is for people with:

Ovarian Cancer

Phase:

Phase 3

Estimated Enrollment:

50

Study ID:

NCT01081262

Recruitment Status:

Active, not recruiting

Sponsor:

National Cancer Institute (NCI)

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There are 206 Locations for this study

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University of Alabama at Birmingham Cancer Center
Birmingham Alabama, 35233, United States
University of South Alabama Mitchell Cancer Institute
Mobile Alabama, 36688, United States
Saint Joseph's Hospital and Medical Center
Phoenix Arizona, 85013, United States
NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
Jonesboro Arkansas, 72401, United States
Providence Saint Joseph Medical Center/Disney Family Cancer Center
Burbank California, 91505, United States
East Bay Radiation Oncology Center
Castro Valley California, 94546, United States
Valley Medical Oncology Consultants-Castro Valley
Castro Valley California, 94546, United States
Bay Area Breast Surgeons Inc
Emeryville California, 94608, United States
Epic Care Partners in Cancer Care
Emeryville California, 94608, United States
Valley Medical Oncology Consultants-Fremont
Fremont California, 94538, United States
Los Angeles General Medical Center
Los Angeles California, 90033, United States
USC / Norris Comprehensive Cancer Center
Los Angeles California, 90033, United States
Contra Costa Regional Medical Center
Martinez California, 94553, United States
El Camino Hospital
Mountain View California, 94040, United States
Highland General Hospital
Oakland California, 94602, United States
Alta Bates Summit Medical Center - Summit Campus
Oakland California, 94609, United States
Bay Area Tumor Institute
Oakland California, 94609, United States
Hematology and Oncology Associates-Oakland
Oakland California, 94609, United States
Tom K Lee Inc
Oakland California, 94609, United States
UC Irvine Health/Chao Family Comprehensive Cancer Center
Orange California, 92868, United States
Doctors Medical Center- JC Robinson Regional Cancer Center
San Pablo California, 94806, United States
Olive View-University of California Los Angeles Medical Center
Sylmar California, 91342, United States
The Medical Center of Aurora
Aurora Colorado, 80012, United States
UCHealth University of Colorado Hospital
Aurora Colorado, 80045, United States
Boulder Community Hospital
Boulder Colorado, 80301, United States
Penrose-Saint Francis Healthcare
Colorado Springs Colorado, 80907, United States
Porter Adventist Hospital
Denver Colorado, 80210, United States
Presbyterian - Saint Lukes Medical Center - Health One
Denver Colorado, 80218, United States
SCL Health Saint Joseph Hospital
Denver Colorado, 80218, United States
Rose Medical Center
Denver Colorado, 80220, United States
Western States Cancer Research NCORP
Denver Colorado, 80222, United States
Swedish Medical Center
Englewood Colorado, 80113, United States
Poudre Valley Hospital
Fort Collins Colorado, 80524, United States
Saint Mary's Hospital and Regional Medical Center
Grand Junction Colorado, 81501, United States
Banner North Colorado Medical Center
Greeley Colorado, 80631, United States
Saint Anthony Hospital
Lakewood Colorado, 80228, United States
Littleton Adventist Hospital
Littleton Colorado, 80122, United States
Sky Ridge Medical Center
Lone Tree Colorado, 80124, United States
Longmont United Hospital
Longmont Colorado, 80501, United States
Banner McKee Medical Center
Loveland Colorado, 80539, United States
Parker Adventist Hospital
Parker Colorado, 80138, United States
Saint Mary Corwin Medical Center
Pueblo Colorado, 81004, United States
North Suburban Medical Center
Thornton Colorado, 80229, United States
SCL Health Lutheran Medical Center
Wheat Ridge Colorado, 80033, United States
Hartford Hospital
Hartford Connecticut, 06102, United States
The Hospital of Central Connecticut
New Britain Connecticut, 06050, United States
Stamford Hospital/Bennett Cancer Center
Stamford Connecticut, 06904, United States
Beebe Medical Center
Lewes Delaware, 19958, United States
Christiana Care Health System-Christiana Hospital
Newark Delaware, 19718, United States
University of Florida Health Science Center - Gainesville
Gainesville Florida, 32610, United States
AdventHealth Orlando
Orlando Florida, 32803, United States
Augusta University Medical Center
Augusta Georgia, 30912, United States
John B Amos Cancer Center
Columbus Georgia, 31904, United States
Northeast Georgia Medical Center-Gainesville
Gainesville Georgia, 30501, United States
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
Savannah Georgia, 31405, United States
Queen's Medical Center
Honolulu Hawaii, 96813, United States
University of Hawaii Cancer Center
Honolulu Hawaii, 96813, United States
Kapiolani Medical Center for Women and Children
Honolulu Hawaii, 96826, United States
OSF Saint Joseph Medical Center
Bloomington Illinois, 61701, United States
Illinois CancerCare-Bloomington
Bloomington Illinois, 61704, United States
Graham Hospital Association
Canton Illinois, 61520, United States
Illinois CancerCare-Canton
Canton Illinois, 61520, United States
Illinois CancerCare-Carthage
Carthage Illinois, 62321, United States
Memorial Hospital
Carthage Illinois, 62321, United States
University of Chicago Comprehensive Cancer Center
Chicago Illinois, 60637, United States
Heartland Cancer Research NCORP
Decatur Illinois, 62526, United States
Eureka Hospital
Eureka Illinois, 61530, United States
Illinois CancerCare-Eureka
Eureka Illinois, 61530, United States
Illinois CancerCare-Galesburg
Galesburg Illinois, 61401, United States
Illinois CancerCare-Havana
Havana Illinois, 62644, United States
Mason District Hospital
Havana Illinois, 62644, United States
Sudarshan K Sharma MD Limited-Gynecologic Oncology
Hinsdale Illinois, 60521, United States
Illinois CancerCare-Kewanee Clinic
Kewanee Illinois, 61443, United States
Illinois CancerCare-Macomb
Macomb Illinois, 61455, United States
Mcdonough District Hospital
Macomb Illinois, 61455, United States
Holy Family Medical Center
Monmouth Illinois, 61462, United States
Illinois CancerCare-Monmouth
Monmouth Illinois, 61462, United States
Bromenn Regional Medical Center
Normal Illinois, 61761, United States
Carle Cancer Institute Normal
Normal Illinois, 61761, United States
Illinois CancerCare-Community Cancer Center
Normal Illinois, 61761, United States
Illinois CancerCare-Ottawa Clinic
Ottawa Illinois, 61350, United States
Ottawa Regional Hospital and Healthcare Center
Ottawa Illinois, 61350, United States
Illinois CancerCare-Pekin
Pekin Illinois, 61554, United States
OSF Saint Francis Radiation Oncology at Pekin
Pekin Illinois, 61554, United States
Proctor Hospital
Peoria Illinois, 61614, United States
Illinois CancerCare-Peoria
Peoria Illinois, 61615, United States
Methodist Medical Center of Illinois
Peoria Illinois, 61636, United States
OSF Saint Francis Medical Center
Peoria Illinois, 61637, United States
Illinois CancerCare-Peru
Peru Illinois, 61354, United States
Illinois Valley Hospital
Peru Illinois, 61354, United States
Illinois CancerCare-Princeton
Princeton Illinois, 61356, United States
Perry Memorial Hospital
Princeton Illinois, 61356, United States
Swedish American Hospital
Rockford Illinois, 61104, United States
Illinois CancerCare-Spring Valley
Spring Valley Illinois, 61362, United States
Elkhart Clinic
Elkhart Indiana, 46514, United States
Michiana Hematology Oncology PC-Elkhart
Elkhart Indiana, 46514, United States
Elkhart General Hospital
Elkhart Indiana, 46515, United States
Indiana University/Melvin and Bren Simon Cancer Center
Indianapolis Indiana, 46202, United States
Ascension Saint Vincent Indianapolis Hospital
Indianapolis Indiana, 46260, United States
Community Howard Regional Health
Kokomo Indiana, 46904, United States
IU Health La Porte Hospital
La Porte Indiana, 46350, United States
Cancer Care Partners LLC
Mishawaka Indiana, 46545, United States
Michiana Hematology Oncology PC-Mishawaka
Mishawaka Indiana, 46545, United States
Saint Joseph Regional Medical Center-Mishawaka
Mishawaka Indiana, 46545, United States
Michiana Hematology Oncology PC-Plymouth
Plymouth Indiana, 46563, United States
Memorial Hospital of South Bend
South Bend Indiana, 46601, United States
Michiana Hematology Oncology PC-South Bend
South Bend Indiana, 46601, United States
South Bend Clinic
South Bend Indiana, 46617, United States
Northern Indiana Cancer Research Consortium
South Bend Indiana, 46628, United States
Michiana Hematology Oncology PC-Westville
Westville Indiana, 46391, United States
Mercy Cancer Center-West Lakes
Clive Iowa, 50325, United States
Mission Cancer and Blood - West Des Moines
Clive Iowa, 50325, United States
Iowa Methodist Medical Center
Des Moines Iowa, 50309, United States
Iowa-Wide Oncology Research Coalition NCORP
Des Moines Iowa, 50309, United States
Mission Cancer and Blood - Des Moines
Des Moines Iowa, 50309, United States
Mercy Medical Center - Des Moines
Des Moines Iowa, 50314, United States
Mission Cancer and Blood - Laurel
Des Moines Iowa, 50314, United States
Iowa Lutheran Hospital
Des Moines Iowa, 50316, United States
Siouxland Regional Cancer Center
Sioux City Iowa, 51101, United States
Mercy Medical Center-Sioux City
Sioux City Iowa, 51102, United States
Saint Luke's Regional Medical Center
Sioux City Iowa, 51104, United States
Methodist West Hospital
West Des Moines Iowa, 50266, United States
Mercy Medical Center-West Lakes
West Des Moines Iowa, 50266, United States
Saint Elizabeth Healthcare Edgewood
Edgewood Kentucky, 41017, United States
University of Kentucky/Markey Cancer Center
Lexington Kentucky, 40536, United States
Pikeville Medical Center
Pikeville Kentucky, 41501, United States
Cancer Center of Acadiana
Lafayette Louisiana, 70503, United States
Ochsner Medical Center Jefferson
New Orleans Louisiana, 70121, United States
Greater Baltimore Medical Center
Baltimore Maryland, 21204, United States
Walter Reed National Military Medical Center
Bethesda Maryland, 20889, United States
Christiana Care - Union Hospital
Elkton Maryland, 21921, United States
Baystate Medical Center
Springfield Massachusetts, 01199, United States
OSF Saint Francis Hospital and Medical Group
Escanaba Michigan, 49829, United States
Green Bay Oncology - Iron Mountain
Iron Mountain Michigan, 49801, United States
Bronson Methodist Hospital
Kalamazoo Michigan, 49007, United States
West Michigan Cancer Center
Kalamazoo Michigan, 49007, United States
Borgess Medical Center
Kalamazoo Michigan, 49048, United States
Corewell Health Lakeland Hospitals - Niles Hospital
Niles Michigan, 49120, United States
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
Saint Joseph Michigan, 49085, United States
Corewell Health Lakeland Hospitals - Saint Joseph Hospital
Saint Joseph Michigan, 49085, United States
University of Mississippi Medical Center
Jackson Mississippi, 39216, United States
Southeast Cancer Center
Cape Girardeau Missouri, 63703, United States
MU Health Care Goldschmidt Cancer Center
Jefferson City Missouri, 65109, United States
Washington University School of Medicine
Saint Louis Missouri, 63110, United States
Missouri Baptist Medical Center
Saint Louis Missouri, 63131, United States
Billings Clinic Cancer Center
Billings Montana, 59101, United States
Saint Vincent Healthcare
Billings Montana, 59101, United States
Montana Cancer Consortium NCORP
Billings Montana, 59102, United States
Saint Vincent Frontier Cancer Center
Billings Montana, 59102, United States
Bozeman Health Deaconess Hospital
Bozeman Montana, 59715, United States
Saint James Community Hospital and Cancer Treatment Center
Butte Montana, 59701, United States
Benefis Sletten Cancer Institute
Great Falls Montana, 59405, United States
Great Falls Clinic
Great Falls Montana, 59405, United States
Northern Montana Hospital
Havre Montana, 59501, United States
Saint Peter's Community Hospital
Helena Montana, 59601, United States
Glacier Oncology PLLC
Kalispell Montana, 59901, United States
Kalispell Medical Oncology
Kalispell Montana, 59901, United States
Kalispell Regional Medical Center
Kalispell Montana, 59901, United States
Montana Cancer Specialists
Missoula Montana, 59802, United States
Saint Patrick Hospital - Community Hospital
Missoula Montana, 59802, United States
Nebraska Methodist Hospital
Omaha Nebraska, 68114, United States
Women's Cancer Center of Nevada
Las Vegas Nevada, 89106, United States
Cooper Hospital University Medical Center
Camden New Jersey, 08103, United States
Virtua Memorial
Mount Holly New Jersey, 08060, United States
Virtua Voorhees
Voorhees New Jersey, 08043, United States
Southwest Gynecologic Oncology Associates Inc
Albuquerque New Mexico, 87106, United States
University of New Mexico Cancer Center
Albuquerque New Mexico, 87106, United States
Stony Brook University Medical Center
Stony Brook New York, 11794, United States
State University of New York Upstate Medical University
Syracuse New York, 13210, United States
UNC Lineberger Comprehensive Cancer Center
Chapel Hill North Carolina, 27599, United States
Duke University Medical Center
Durham North Carolina, 27710, United States
Wayne Memorial Hospital
Goldsboro North Carolina, 27534, United States
AdventHealth Hendersonville
Hendersonville North Carolina, 28792, United States
Southeast Clinical Oncology Research Consortium NCORP
Winston-Salem North Carolina, 27104, United States
Wake Forest University Health Sciences
Winston-Salem North Carolina, 27157, United States
Mid Dakota Clinic
Bismarck North Dakota, 58501, United States
Saint Alexius Medical Center
Bismarck North Dakota, 58501, United States
Sanford Bismarck Medical Center
Bismarck North Dakota, 58501, United States
Summa Health System - Akron Campus
Akron Ohio, 44304, United States
Mary Rutan Hospital
Bellefontaine Ohio, 43311, United States
Aultman Health Foundation
Canton Ohio, 44710, United States
Adena Regional Medical Center
Chillicothe Ohio, 45601, United States
University of Cincinnati Cancer Center-UC Medical Center
Cincinnati Ohio, 45219, United States
Good Samaritan Hospital - Cincinnati
Cincinnati Ohio, 45220, United States
Bethesda North Hospital
Cincinnati Ohio, 45242, United States
Case Western Reserve University
Cleveland Ohio, 44106, United States
MetroHealth Medical Center
Cleveland Ohio, 44109, United States
Cleveland Clinic Cancer Center/Fairview Hospital
Cleveland Ohio, 44111, United States
Cleveland Clinic Foundation
Cleveland Ohio, 44195, United States
Ohio State University Comprehensive Cancer Center
Columbus Ohio, 43210, United States
Mount Carmel East Hospital
Columbus Ohio, 43213, United States
Riverside Methodist Hospital
Columbus Ohio, 43214, United States
Columbus NCI Community Oncology Research Program
Columbus Ohio, 43215, United States
Grant Medical Center
Columbus Ohio, 43215, United States
The Mark H Zangmeister Center
Columbus Ohio, 43219, United States
Mount Carmel Health Center West
Columbus Ohio, 43222, United States
Doctors Hospital
Columbus Ohio, 43228, United States
Grady Memorial Hospital
Delaware Ohio, 43015, United States
Kettering Medical Center
Kettering Ohio, 45429, United States
Fairfield Medical Center
Lancaster Ohio, 43130, United States
Marietta Memorial Hospital
Marietta Ohio, 45750, United States
Hillcrest Hospital Cancer Center
Mayfield Heights Ohio, 44124, United States
UH Seidman Cancer Center at Lake Health Mentor Campus
Mentor Ohio, 44060, United States
Knox Community Hospital
Mount Vernon Ohio, 43050, United States
Licking Memorial Hospital
Newark Ohio, 43055, United States
Southern Ohio Medical Center
Portsmouth Ohio, 45662, United States
Springfield Regional Medical Center
Springfield Ohio, 45504, United States
Saint Ann's Hospital
Westerville Ohio, 43081, United States
Genesis Healthcare System Cancer Care Center
Zanesville Ohio, 43701, United States
University of Oklahoma Health Sciences Center
Oklahoma City Oklahoma, 73104, United States
Oklahoma Cancer Specialists and Research Institute-Tulsa
Tulsa Oklahoma, 74146, United States
Jefferson Abington Hospital
Abington Pennsylvania, 19001, United States
Saint Luke's University Hospital-Bethlehem Campus
Bethlehem Pennsylvania, 18015, United States
Geisinger Medical Center
Danville Pennsylvania, 17822, United States
Geisinger Medical Center-Cancer Center Hazleton
Hazleton Pennsylvania, 18201, United States
University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh Pennsylvania, 15232, United States
Geisinger Medical Group
State College Pennsylvania, 16801, United States
Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre Pennsylvania, 18711, United States
Women and Infants Hospital
Providence Rhode Island, 02905, United States
AnMed Health Cancer Center
Anderson South Carolina, 29621, United States
AnMed Health Hospital
Anderson South Carolina, 29621, United States
Saint Francis Hospital
Greenville South Carolina, 29601, United States
Spartanburg Medical Center
Spartanburg South Carolina, 29303, United States
Sanford Cancer Center Oncology Clinic
Sioux Falls South Dakota, 57104, United States
Sanford USD Medical Center - Sioux Falls
Sioux Falls South Dakota, 57117, United States
University of Tennessee - Knoxville
Knoxville Tennessee, 37920, United States
Parkland Memorial Hospital
Dallas Texas, 75235, United States
UT Southwestern/Simmons Cancer Center-Dallas
Dallas Texas, 75390, United States
University of Texas Medical Branch
Galveston Texas, 77555, United States
Houston Methodist Hospital
Houston Texas, 77030, United States
M D Anderson Cancer Center
Houston Texas, 77030, United States
Memorial Hermann Texas Medical Center
Houston Texas, 77030, United States
Danville Regional Medical Center
Danville Virginia, 24541, United States
Hematology Oncology Associates of Fredericksburg Inc
Fredericksburg Virginia, 22408, United States
Centra Alan B Pearson Regional Cancer Center
Lynchburg Virginia, 24501, United States
Green Bay Oncology at Saint Vincent Hospital
Green Bay Wisconsin, 54301, United States
Saint Vincent Hospital Cancer Center Green Bay
Green Bay Wisconsin, 54301, United States
Green Bay Oncology Limited at Saint Mary's Hospital
Green Bay Wisconsin, 54303, United States
Saint Vincent Hospital Cancer Center at Saint Mary's
Green Bay Wisconsin, 54303, United States
Gundersen Lutheran Medical Center
La Crosse Wisconsin, 54601, United States
Holy Family Memorial Hospital
Manitowoc Wisconsin, 54221, United States
Bay Area Medical Center
Marinette Wisconsin, 54143, United States
Aurora Saint Luke's Medical Center
Milwaukee Wisconsin, 53215, United States
Medical College of Wisconsin
Milwaukee Wisconsin, 53226, United States
Aurora Sinai Medical Center
Milwaukee Wisconsin, 53233, United States
Saint Vincent Hospital Cancer Center at Oconto Falls
Oconto Falls Wisconsin, 54154, United States
Vince Lombardi Cancer Clinic-Sheboygan
Sheboygan Wisconsin, 53081, United States
Green Bay Oncology - Sturgeon Bay
Sturgeon Bay Wisconsin, 54235, United States
Aurora Medical Center in Summit
Summit Wisconsin, 53066, United States
Aurora West Allis Medical Center
West Allis Wisconsin, 53227, United States
Rocky Mountain Oncology
Casper Wyoming, 82609, United States
Welch Cancer Center
Sheridan Wyoming, 82801, United States

How clear is this clinincal trial information?

Study is for people with:

Ovarian Cancer

Phase:

Phase 3

Estimated Enrollment:

50

Study ID:

NCT01081262

Recruitment Status:

Active, not recruiting

Sponsor:


National Cancer Institute (NCI)

How clear is this clinincal trial information?

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