Cisplatin and Flavopiridol in Treating Patients With Advanced Ovarian Epithelial Cancer or Primary Peritoneal Cancer

Inclusion Criteria:

Histologically confirmed ovarian epithelial or primary peritoneal cancer:

Advanced disease

Meets at least 1 of the following criteria:

Measurable disease;
Evaluable disease plus CA 125 >= 2 times post-treatment nadir
Treated with 1, and only 1, prior platin-containing chemotherapy regimen (e.g., paclitaxel or carboplatin-based) for ovarian epithelial or primary peritoneal cancer

Prior treatment with the same regimen at first relapse allowed;

No more than 3 total chemotherapy regimens allowed provided exactly 1 has been platin-containing;
Must also have platin-resistant disease as defined for Group 1;
Rechallenge with a single regimen upon progression after a hiatus from therapy counts as a single regimen

Group 1, meeting 1 of the following criteria:

Patients who relapse during or < 6 months after completion of post-debulking chemotherapy;
"Platinum sensitive" patients in second relapse after having been treated/rechallenged with their initial regimen upon first relapse

Group 2 (Closed to accrual as of 3/10/06):

Patients who relapse >= 6 months after completion of post-debulking chemotherapy and are not retreated with the same or a different regimen
No CNS metastases

Performance status:

ECOG 0-2

Hematopoietic:

Absolute neutrophil count >= 1,500/mm3;
Platelet count >= 100,000/mm3;
Hemoglobin >= 10 g/dL (Note: May be supported with transfusion, epoetin alfa, or darbepoetin alfa)

Hepatic:

AST =< 2.5 times upper limit of normal (ULN);
Alkaline phosphatase =< 2.5 times ULN;
Bilirubin =< 1.5 times ULN

Renal:

Creatinine =< 1.5 times ULN

Cardiovascular:

No cardiac arrhythmia;
No cardiac failure
Not pregnant or nursing
Negative pregnancy test
More than 3 weeks since prior chemotherapy (6 weeks for nitrosoureas)
More than 3 weeks since prior radiotherapy
Recovered from all prior therapy
Fertile patients must use effective contraception
No other malignancy within the past 5 years except non-melanoma skin cancer or carcinoma in situ of the cervix
No diabetes
No peripheral neuropathy >= grade 2
No baseline diarrhea (>= 4 stools/day)
No uncontrolled infection
No other concurrent uncontrolled serious medical condition
No concurrent routine colony-stimulating factors