Combination Chemotherapy and Bone Marrow Transplant in Treating Patients With Refractory or Recurrent Ovarian Cancer

DISEASE CHARACTERISTICS:

Diagnosis of refractory or relapsed ovarian epithelial cancer

Must have failed prior regimen containing cisplatin or carboplatin

Bidimensionally measurable or evaluable disease

Serial CA-125 antigen titers or cytologically positive pleural effusion and/or ascites acceptable as evaluable disease
Autologous bone marrow harvest of greater than 1.2 x 10 to the eighth nucleated cells/kg required before study entry
No evidence of tumor at marrow harvest sites by bilateral bone marrow aspirates and biopsies, pelvic x-ray, and bone scan
CNS involvement allowed

PATIENT CHARACTERISTICS:

Age:

Under 65

Performance status:

SWOG 0-2

Life expectancy:

At least 8 weeks

Hematopoietic:

WBC greater than 3,500/mm^3
Platelet count greater than 100,000/mm^3
Hemoglobin greater than 10.0 g/dL

Hepatic:

Bilirubin less than 2.0 mg/dL
SGOT and SGPT less than 2 times upper limit of normal

Renal:

Creatinine clearance greater than 60 mL/min
No prior hemorrhagic cystitis

Cardiovascular:

LVEF greater than 45% by MUGA scan

Other:

No hearing loss in voice tones
No active infection
No psychological contraindication to study treatment
Not pregnant
Negative pregnancy test
HIV negative
General medical condition must allow general anesthesia

PRIOR CONCURRENT THERAPY:

Biologic therapy:

See Disease Characteristics
No prior bone marrow transplantation
More than 4 weeks since other prior biologic therapy and recovered

Chemotherapy:

See Disease Characteristics
More than 4 weeks since prior chemotherapy (at least 6 weeks for nitrosoureas or mitomycin) and recovered

Endocrine therapy:

Not specified

Radiotherapy:

More than 4 weeks since prior radiotherapy and recovered

Surgery:

Not specified