Ovarian Cancer Clinical Trial
Expanded Access to Ulixertinib (BVD-523) in Patients With Advanced MAPK Pathway-Altered Malignancies
Summary
The objective of this expanded access program is to provide ulixertinib (BVD-523) for compassionate use in advanced cancer patients with MAPK pathway-altered solid tumor(s), including but not limited to KRAS, NRAS, HRAS, BRAF, MEK, and ERK mutations who have incomplete response to or have exhausted available therapies.
Eligibility Criteria
Inclusion Criteria:
Main Inclusion Criterion:
1. Patient has a MAPK pathway-altered solid tumor(s), including but not limited to KRAS, NRAS, HRAS, BRAF, MEK, and ERK mutations.
Other Inclusion Criteria:
In the opinion of the treating physician, the patient has exhausted or has inadequate response to available anti-cancer treatments.
In the opinion of the treating physician, the patient has adequate organ function to tolerate ulixertinib as defined in section 6.1
Male or female patients aged ≥ 12 years.
Patient must be able to swallow and retain orally administered medication.
Note: Ulixertinib is primarily absorbed in the duodenum and therefore patients with any prior stomach or duodenal resection should be evaluated with that understanding.
For females, evidence of post-menopausal status or negative urinary or serum pregnancy test for pre-menopausal patients.
Highly effective contraception for both male and female patients throughout the treatment and for at least 4 months after last treatment administration. In patients under the age of 18, who are not sexually active, abstinence is an acceptable form.
Toxicities related to any prior treatments are either stable, stable on supportive therapy, resolved, or in the opinion of the treating physician, clinically non-significant
Ability to understand a written informed consent document, and the willingness to sign it. Assent will be obtained when appropriate based on the patient's age.
Exclusion Criteria:
Patient is already participating in or qualifies for and is able to enroll in a clinical trial of ulixertinib (BVD-523).
Patient has received systemic therapy with an investigational agent within 5 half-lives or 14 days prior to starting ulixertinib treatment, whichever is shorter.
Patient has received radiotherapy within 14 days prior to the first dose of ulixertinib treatment other than for the allowable treatment of symptomatic bone metastasis.
A history of current evidence/risk of retinal vein occlusion (RVO) or central serous retinopathy (CSR)
Current evidence of uncontrolled, significant intercurrent illness that would, in the treating physician's judgment, contraindicate the patient's treatment with ulixertinib due to safety concerns.
Patients who, in the opinion of the treating physician, have not fully recovered from recent major surgery to a sufficient extent to tolerate treatment with ulixertinib.
Known hypersensitivity to ulixertinib or any component in its formulation.
Patients taking prohibited medications as described in current Investigator's Brochure.
Note: Patients who require treatment with Drugs that are strong inhibitors or inducers of CYP1A2, CYP2D6, and CYP3A4 (see Appendix 3) were excluded from the FIH study of ulixertinib and should be discussed with xCures to review if any potential benefits outweigh the potential risks.
Patient is actively breastfeeding.
Prior stomach or duodenal resection that in the opinion of the treating physician would affect the breakdown and absorption of ulixertinib.
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There are 24 Locations for this study
Birmingham Alabama, 35294, United States More Info
Principal Investigator
Huntsville Alabama, 35805, United States More Info
Principal Investigator
Mobile Alabama, 36604, United States More Info
Principal Investigator
Arroyo Grande California, 93420, United States More Info
Principal Investigator
Los Angeles California, 90027, United States More Info
Principal Investigator
Newport Beach California, 92663, United States More Info
Principal Investigator
San Francisco California, 94105, United States
Santa Monica California, 90404, United States More Info
Principal Investigator
Washington District of Columbia, 20007, United States More Info
Principal Investigator
Orlando Florida, 32806, United States More Info
Principal Investigator
Des Moines Iowa, 50309, United States More Info
Principal Investigator
Baton Rouge Louisiana, 70809, United States More Info
Principal Investigator
Augusta Maine, 04330, United States More Info
Principal Investigator
Bar Harbor Maine, 04609, United States More Info
Principal Investigator
Sterling Heights Michigan, 48314, United States More Info
Principal Investigator
Lincoln Nebraska, 68510, United States More Info
Principal Investigator
Long Branch New Jersey, 07740, United States More Info
Principal Investigator
Mickleton New Jersey, 08056, United States More Info
Principal Investigator
Summit New Jersey, 07901, United States More Info
Principal Investigator
Stony Brook New York, 11794, United States More Info
Principal Investigator
Cincinnati Ohio, 45219, United States More Info
Principal Investigator
Toledo Ohio, 43623, United States More Info
Principal Investigator
Allentown Pennsylvania, 18103, United States More Info
Principal Investigator
Seattle Washington, 98109, United States More Info
Principal Investigator
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