Ovarian Cancer Clinical Trial

Fc-Engineered Anti-CTLA-4 Monoclonal Antibody in Advanced Cancer

Summary

This study is an open-label, Phase 1, multicenter study to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamic (PD) profiles of a novel fragment crystallizable (Fc)-engineered immunoglobulin G1 anti-cytotoxic T-lymphocyte antigen 4 (anti-CTLA-4) human monoclonal antibody (botensilimab) monotherapy and in combination with an anti-programmed cell death protein-1 (PD-1) antibody (balstilimab), and to assess the maximum tolerated dose (MTD) in participants with advanced solid tumors. This study will also determine the recommended phase 2 dose (RP2D) of botensilimab monotherapy and in combination with balstilimab.

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Full Description

This Phase 1 study will enroll up to approximately 450 evaluable adult participants with refractory cancer (solid tumors) regardless of diagnosis.

The study will consist of a 3+3 dose escalation. Different dose levels of botensilimab, both monotherapy and in combination with balstilimab, will be evaluated in individual cohorts based upon dose. Each participant will remain in the cohort of the dose level and schedule assigned at study entry. Participants can be replaced for any reason other than a dose-limiting toxicity (DLT). Participants will receive treatment for ≤ 2 years or until progressive disease, unacceptable toxicity, or any criterion for stopping the study drug or withdrawal of trial occurs.

Additionally, the study is intended to further explore the safety, PK, PD, and clinical activity in selected cancer types at dose levels (botensilimab monotherapy and combination therapy with balstilimab) determined as potentially effective. Indications of interest include, but are not limited to, non-small-cell lung cancer, melanoma, endometrial cancer, ovarian cancer, angiosarcoma, colorectal cancer without liver metastases, prostate cancer, and fibrolamellar carcinoma.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

For inclusion in the trial, all of the following inclusion criteria must be fulfilled, as no waivers will be permitted:

Provision of signed and dated written informed consent prior to any study specific procedures. Participation in pharmacogenomics testing is optional.
Histologically or cytologically confirmed diagnosis of metastatic or locally advanced solid tumor for which no standard therapy is available or standard therapy has failed.
Measurable disease on imaging based on RECIST 1.1, except for prostate cancer.
Life expectancy of ≥ 3 months and Eastern Cooperative Oncology Group performance status of 0 or 1.

Adequate organ and bone marrow reserve function, as indicated by the following laboratory values:

Adequate hematological function, defined as absolute neutrophil count ≥ 1.5 × 10^9/liter (L), platelet count ≥ 100 × 10^9/L, and hemoglobin ≥ 8 grams/deciliter without recent transfusion (defined as a transfusion that has occurred within 2 weeks of the hemoglobin measurement).
Adequate liver function, defined as total bilirubin level ≤ 1.5 × institutional upper limit of normal (IULN) (except for participants with Gilbert syndrome who must have a total bilirubin level of ≤ 3.0 × IULN), aspartate aminotransferase ≤ 2.5 × IULN, and alanine aminotransferase ≤ 2.5 × IULN.
Adequate renal function defined as creatinine ≤ 1.5 × IULN or measured or calculated creatinine clearance ≥ 40 milliliters (mL)/minute per institutional standard. Assessment methods should be recorded.
Adequate coagulation, defined as international normalized ratio or prothrombin time ≤ 1.5 × IULN and activated partial thromboplastin time ≤ 1.5 × IULN (unless participant receiving anticoagulant therapy) or stable known coagulopathy with sponsor approval.
No history of prior or concomitant malignancy that requires other active treatment.
A sufficient and adequate formalin-fixed paraffin embedded tumor tissue sample (fresh or archival tumor tissue) collected since last treatment and before the first dose from a site not previously irradiated, if clinically feasible.

Female participants of childbearing potential must have a negative serum pregnancy test at screening (within 72 hours of first dose of study medication). Non-childbearing potential is defined as 1 of the following:

≥ 45 years of age and has not had menses for > 1 year.
Amenorrheic for > 2 years without a hysterectomy and/or oophorectomy and follicle stimulating hormone value in the postmenopausal range upon pretrial (screening) evaluation.
Status is post-hysterectomy, -oophorectomy, or -tubal ligation.
Female participants of childbearing potential must be willing to use highly effective contraceptive measures starting with the Screening visit through 90 days after last dose of study treatment. Note: Abstinence is acceptable if this is the established and preferred contraception for the participant.

Male participants with a female partner(s) of childbearing potential must agree to use highly effective contraceptive measures throughout the trial starting with the Screening visit through 90 days after the last dose of study treatment is received. Males with pregnant partners must agree to use a condom; no additional method of contraception is required for the pregnant partner. Note: Abstinence is acceptable if this is the established and preferred contraception method for the participant.

The following inclusion criteria are in addition to the above criteria. If there are criteria below that differs from above, the below indication-specific criteria take precedence.

Additional Inclusion Criteria for Angiosarcoma Cohort

Histologically or cytologically confirmed diagnosis of metastatic or locally advanced angiosarcoma for which no standard therapy is available or standard therapy has failed.

Additional Inclusion Criteria for the Hepatocellular Cancer (HCC) Cohort

Histologically or cytologically confirmed diagnosis or radiological diagnosis following the guidelines from the American Association for the Study of Liver Diseases of metastatic or locally advanced HCC.
Must have progressed while receiving, or following, programmed death-ligand 1 (PD(L)-1)-based therapy.
Child-Pugh score of A. Note: Participants on anticoagulant treatment would have an assigned value of 1 point when scoring prothrombin time/international normalized ratio so the overall Child-Pugh score is not adversely affected.

Adequate organ and bone marrow reserve function as indicated by the following laboratory values:

Platelet count ≥ 60 × 10^6/cubic millimeter (mm^3) and absolute neutrophil count ≥ 1,000 × 10^6/L are acceptable provided that the investigator assesses these abnormalities as being due to liver disease.
Adequate liver function, defined as aspartate aminotransferase and alanine aminotransferase ≤ 5 × IULN, bilirubin ≤ 2 × IULN.

Participants are eligible to enroll if they have non-viral-HCC or if they have hepatitis B (HBV), or hepatitis C virus (HCV) related HCC, defined as follows:

Chronic HBV infection as evidenced by detectable HBV surface antigen or HBV DNA. Participants with chronic HBV infection must be on antiviral therapy and have HBV DNA < 500 international units/mL.
Active or resolved HCV infection as evidenced by detectable HCV RNA or antibody.

Additional Inclusion Criteria for the Non-Small Cell Lung Cancer (NSCLC) Cohort

Histologically or cytologically confirmed diagnosis of metastatic or locally advanced NSCLC for which no standard therapy is available or standard therapy has failed:

Adenocarcinoma or squamous cell carcinoma at the time of enrollment. If other histologies are also present, must be approved by the medical monitor prior to study entry.
For participants without targetable alterations: Prior treatment with anti PD(L)-1-based therapy.
Participants with targetable alterations (for example, estimated glomerular filtration rate, anaplastic lymphoma kinase, Kirsten rat sarcoma virus-single point mutation with a glycine-to-cysteine substitution at codon 12, reactive oxygen species, mesenchymal epithelial transition factor receptor, etc.): must have received or be intolerant of at least one approved targeted therapy.

Additional Inclusion Criteria for the Prostate Cancer Cohort

Diagnosis of metastatic castrate resistant prostate cancer.

Must have demonstrated serologic or radiographic progression on or following the most recent therapy in the setting of castrate-level testosterone (< 50 nanograms per mL [ng/mL] and/or maintained on medical/surgical castration throughout) as defined by at least one of the following:

Baseline PSA ≥ 2.0 ng/mL and 2 sequential rises in prostate-specific antigen (PSA) with each rising value being at least 1 week apart.
Progression by RECIST 1.1.
Progression by PCWG3 criteria for bone disease ("2+2" rule) with or without PSA progression.

Must maintain castration status defined as serum testosterone < 50 ng/mL. Must be either surgically castrate or on luteinizing hormone-releasing hormone analog for the duration of the study.

Additional Inclusion Criteria for Breast Cancer

Must have received PD-(L)1 therapy if indicated. Note: Premenopausal participants may continue ongoing ovarian suppression on study. Permitted agents are goserelin, triptorelin or analogs.

Exclusion Criteria:

For inclusion in the trial, participant must meet none of the following exclusion criteria, as no waivers will be permitted:

Currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigation device within 3 weeks of first dose of current study drug.
Received prior systemic cytotoxic chemotherapy, biological therapy, radiotherapy, or major surgery within 3 weeks prior to first dose of study drug; for tyrosine kinase inhibitor or similar within 4 × half-life prior to first dose of study drug. A 1-week washout is permitted for palliative radiation to non-central nervous system disease, with Sponsor approval.
Participants who have received prior CTLA-4 therapy may be enrolled in selected indications upon agreement with the Sponsor.
Persistent toxicity of NCI CTCAE version 5.0 Grade > 1 severity that is related to prior therapy. Note: Sensory neuropathy, hypothyroidism or alopecia of Grade ≤ 2 are acceptable. Other Grade 2 toxicities of prior treatments that are controlled with medication (for example, diabetes or hypertension) may be permitted with sponsor approval.
Expected to require any other form of systemic or localized antineoplastic therapy while on trial (including maintenance therapy with another agent, radiation therapy, and/or surgical resection).

History of:

Severe (Grade ≥ 3) hypersensitivity reaction to a fully human monoclonal antibodies
Immune-related adverse event requiring treatment with systemic steroids for > 7 days excluding Grade 1 or 2 rash.
Interstitial lung disease or lung disease which may interfere with the assessment of pneumonitis.
Uncontrolled asthma (that is, ≥ 3 features of partly controlled asthma)
Pneumonitis that has required oral or IV corticosteroids.
Receiving systemic corticosteroid therapy 1 week prior to the first dose of study drug or receiving any other form of systemic immunosuppressive medication. Note: Corticosteroid use as a premedication for IV contrast allergies/reactions is allowed. Participants who are receiving daily corticosteroid replacement therapy are also an exception to this rule. Daily prednisone at doses of ≤ 7.5 mg or equivalent hydrocortisone dose are examples of permitted replacement therapy. Use of inhaled or topical corticosteroids is permitted.
Brain metastases or leptomeningeal metastases with the following exceptions: Note: Brain metastases which have been treated with either surgical resection or stereotactic radio surgery. These participants must be off steroids ≥ 10 days prior to randomization for the purpose of managing their brain metastases. Repeat brain imaging following surgical resection or stereotactic radiosurgery is not required if their last brain magnetic resonance imaging is within screening window. Prior whole-brain radiation may be permitted only with sponsor approval. Note: Untreated isolated brain metastases that are too small for treatment by surgical resection or stereotactic radiosurgery (for example, 1-2 mm) and/or of uncertain etiology are potentially eligible but must be approved by the sponsor.
Active or history of autoimmune disease that requires systemic treatment within 2 years of the start of study drug (that is, with use of disease-modifying agents, corticosteroids, or immunosuppressive drugs). Note: Participants with autoimmune conditions requiring hormone replacement therapy or topical treatments are eligible.
Has had an allogeneic tissue/solid organ transplant, except for corneal transplants.
Active infection requiring systemic treatment.
Known history of human immunodeficiency virus type 1 or 2 antibodies.
Known active infection with hepatitis B and/or hepatitis C virus.
Clinically significant (that is, active) cardiovascular disease: cerebral vascular accident/stroke or myocardial infarction within 6 months of enrollment, unstable angina, congestive heart failure (New York Heart Association class ≥ II), or serious uncontrolled cardiac arrhythmia requiring medication.
History or current evidence of any condition, therapy, any active infections, or laboratory abnormality that might confound the results of the trial, interfere with the participant's participation for the full duration of the trial, or is not in the best interest of the participant to participate, in the opinion of the treating Investigator.
Known psychiatric or substance abuse disorder that would interfere with cooperation with the requirements of the study.
Legally incapacitated or has limited legal capacity.
Pregnant or breastfeeding.

Concurrent malignancy requiring treatment or history of prior malignancy active within 2 years prior to the first dose of study treatment. Exceptions: participants with completely resected prior early-stage basal/squamous cell skin cancer or treated cervical carcinoma in situ.

The following exclusion criteria are in addition to the above criteria. If there are criteria below that differs from above, the below indication-specific criteria take precedence.

Additional Exclusion Criteria for the HCC Cohort

Received locoregional therapy (for example, transcatheter chemoembolization, radiation, surgery) within 6 weeks or yttrium-90 within 12 weeks.
Hepatic encephalopathy within the last 6 months requiring admission or initiation of or intensification of therapy. Participants taking rifaximin/lactulose as encephalopathy prophylaxis are allowed as long as they have not had clinically evident encephalopathy in the past 6 months.
Gastro-esophageal varices bleeding in the last 6 months.
Ascites requiring paracentesis within the last 3 months. Participants with previous ascites that is managed with stable doses of diuretics and have a Child Pugh score of A are allowed.

Study is for people with:

Ovarian Cancer

Phase:

Phase 1

Estimated Enrollment:

450

Study ID:

NCT03860272

Recruitment Status:

Recruiting

Sponsor:

Agenus Inc.

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There are 14 Locations for this study

See Locations Near You

HonorHealth Research Institute
Scottsdale Arizona, 85258, United States More Info
Clinical Trials Nurse Navigation
Contact
480-323-1364
[email protected]
Michael Gordon, MD
Principal Investigator
City of Hope Comprehensive Cancer Center
Duarte California, 91010, United States More Info
Erin Morones
Contact
[email protected]
Marwan G Fakih, MD
Principal Investigator
The Angeles Clinic & Research Institute, a Cedars-Sinai Affiliate
Los Angeles California, 90025, United States More Info
Teri Mata
Contact
310-231-2115
[email protected]
Ani Balmanoukian, MD
Principal Investigator
University of Southern California Norris Comprehensive Cancer Center
Los Angeles California, 90033, United States More Info
Igor Gorodniuk
Contact
323-409-4365
[email protected]
Anthony El-Khoueiry, MD
Principal Investigator
Saint John's Cancer Institute
Santa Monica California, 90404, United States More Info
Irving Ledesma
Contact
310-582-7047
[email protected]
Kim Margolin, MD
Principal Investigator
University of Colorado
Aurora Colorado, 80045, United States More Info
Meghan Ayers
Contact
720-848-5278
[email protected]
Breelyn Wilky, MD
Principal Investigator
University of Miami Sylvester Comprehensive Cancer Center
Miami Florida, 33136, United States More Info
Marialby Donis Ramos
Contact
305-243-8237
[email protected]
Jonathan Trent, MD
Principal Investigator
Beth Israel Deaconess Medical Center
Boston Massachusetts, 02215, United States More Info
Alisa Posner
Contact
617-975-7433
[email protected]
Bruno Buckorny, MD
Principal Investigator
Dana-Farber Cancer Institute
Boston Massachusetts, 02215, United States More Info
Benjamin Schlechter, MD
Contact
617-632-3000
[email protected]
Benjamin Schlechter, MD
Principal Investigator
Columbia University Medical Center
New York New York, 10032, United States More Info
Ellen Alt
Contact
212-304-5545
[email protected]
Gary K Schwartz, MD
Principal Investigator
Memorial Sloan Kettering Cancer Center
New York New York, 10065, United States More Info
Amin Yaqubie
Contact
212-639-2000
[email protected]
Olivia Heffernan
Contact
212-639-2000
[email protected]
Ghassan Khaled Abou-Alfa, MD
Principal Investigator
Ohio State University
Columbus Ohio, 43210, United States
Providence Portland Cancer Center
Portland Oregon, 97213, United States More Info
Melissa Ngirailemesang, RN
Contact
503-215-2714
[email protected]
Rachel E Sanborn, MD
Principal Investigator
MD Anderson Cancer Center
Houston Texas, 77030, United States More Info
Becky Norris
Contact
[email protected]
Apostolia Tsimberidou, MD, PhD
Principal Investigator
The University of Texas Health Science Center at San Antonio
San Antonio Texas, 78229, United States More Info
Hope Moreno, RN
Contact
[email protected]
Mahadevan Daruka, MD
Principal Investigator

How clear is this clinincal trial information?

Study is for people with:

Ovarian Cancer

Phase:

Phase 1

Estimated Enrollment:

450

Study ID:

NCT03860272

Recruitment Status:

Recruiting

Sponsor:


Agenus Inc.

How clear is this clinincal trial information?

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