Intravenous Palifosfamide-tris in Combination With Etoposide and Carboplatin in Patients With Malignancies

Inclusion Criteria:

18 years old or greater
Malignancy scheduled to receive etoposide and carboplatin therapy
Eastern Cooperative Oncology Group (ECOG) performance of 0 or 1
Adequate bone marrow, liver, renal function and coagulation status
Informed consent
Agree to use birth control through 28 days of last treatment dose
Pregnancy test for women of child-bearing potential
No available standard therapy

Exclusion Criteria:

Allergy to the the study treatment drugs
Unstable current medical condition
Presence or history of injury to the urinary tract
Active infection
Major surgery within 4 weeks prior to treatment
Minor surgery within 2 weeks prior to treatment
Current acute steroid therapy or taper
Currently pregnant or nursing
Substance abuse or condition that may interfere with participation
Received other investigational drugs within 30 days
Within 4 weeks of their last chemotherapy