Ovarian Cancer Clinical Trial

Laboratory Study of Cancer & Immune Cells in Ascites Fluid of Ovarian Cancer Patients to Test Alternative Therapies

Summary

Ascites samples from women undergoing surgery for ovarian cancer will be collected for use in translational research.

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Full Description

The purpose of this study is to collect ascites fluid obtained from ovarian cancer patients during cytoreductive surgery or paracentesis at the University of New Mexico Hospital or Cancer Center. Cancer cells and immune cells from the ascites fluid will be used to test novel immunotherapies for ovarian cancer treatment and to establish patient derived xenograft models to perform preclinical testing on a cancer cell population that better models the heterogeneity in patient disease

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Eligibility Criteria

Inclusion Criteria:

All female participants, regardless of ethnicity, who are undergoing cytoreductive surgery for ovarian cancer are eligible for this study
All participants will be eighteen years old or older
Patients must be suspected of having a pathological diagnosis or clinical suspicion of ovarian cancer and be scheduled for surgery for tumor resection.
Ability to understand and the willingness to sign a written informed consent document.
Pathologic confirmation of a diagnosis of epithelial adenocarcinoma of the ovary, fallopian tube, or primary peritoneal cancer (serous, mucinous, clear cell, endometrioid, undifferentiated, mixed, transitional cell)
Women of childbearing potential must have a negative qualitative serum pregnancy test ≤ 2 weeks prior to study entry.

A female of child-bearing potential is any woman (regardless of sexual orientation, having undergone a tubal ligation, or remaining celibate by choice) who meets the following criteria:

Has not undergone a hysterectomy or bilateral oophorectomy; or
Has not been naturally postmenopausal for at least 12 consecutive months (i.e., has had menses at any time in the preceding 12 consecutive months).

Exclusion Criteria:

We do not intend to include participants if they are unable to provide informed consent for this study themselves (e.g. mentally ill patients who require health care proxies to consent for any medical intervention), or vulnerable populations such as prisoners.
Minors under age eighteen.
Pregnant women.
Final pathologic diagnosis that does not confirm invasive epithelial ovarian, tubal, or primary peritoneal cancer

Study is for people with:

Ovarian Cancer

Estimated Enrollment:

100

Study ID:

NCT03943316

Recruitment Status:

Recruiting

Sponsor:

New Mexico Cancer Care Alliance

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There is 1 Location for this study

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University of New Mexico Cancer Center
Albuquerque New Mexico, 87131, United States More Info
Amy Overby
Contact
505-272-5557
[email protected]
Sharareh Sazesh, MS
Contact
[email protected]
Sarah Adams, MD
Principal Investigator
Carolyn Muller, MD
Sub-Investigator
Bridget Wilson, PhD
Sub-Investigator
Laurie Hudson, PhD
Sub-Investigator
Angela Wandinger-Ness, PhD
Sub-Investigator
Helen Hathaway, PhD
Sub-Investigator
Eric Prossnitz, PhD
Sub-Investigator
Mara Steinkamp, PhD
Sub-Investigator
Sabrina Samudio-Ruiz, PhD
Sub-Investigator

How clear is this clinincal trial information?

Study is for people with:

Ovarian Cancer

Estimated Enrollment:

100

Study ID:

NCT03943316

Recruitment Status:

Recruiting

Sponsor:


New Mexico Cancer Care Alliance

How clear is this clinincal trial information?

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