Ovarian Cancer Clinical Trial

Study of Gemcitabine/Carboplatin/Bevacizumab to Treat Ovarian, Fallopian Tube or Primary Peritoneal Cancer

Summary

The purpose of this study is to test the effectiveness, safety and tolerability of the drug combination: gemcitabine, carboplatin and bevacizumab in patients that have been diagnosed with platinum sensitive recurrent ovarian cancer, fallopian tube or primary peritoneal cancer.

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Full Description

In this study participants will receive the drug combination gemcitabine/carboplatin and bevacizumab once every two weeks. As long as there is evidence that the tumor is not growing and the participant is not experiencing any unacceptable side effects, participation can continue up to 2 years. The study is being done to find the effectiveness, safety and tolerability of this combination of chemotherapy drugs. Bevacizumab affects the growth of new blood vessels in the body. It is part of this study to see if stopping the growth of new blood vessels in the body will help stop the growth and the spread of cancer. The other two chemotherapy drugs, gemcitabine and carboplatin, are currently being used together for the treatment of ovarian cancer.

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Eligibility Criteria

Inclusion Criteria:

Cancer of the ovaries, fallopian tube or abdominal lining has come back after more than 6 months from the last platinum based chemotherapy treatment.
Disease must be detected by CT or CA125 level must be elevated or cancerous ascites must be present.
History of at least one therapy of platinum based chemotherapy.

Exclusion Criteria:

Participation in another experimental drug study
Heart disease or high blood pressure
History of a stroke within the past 6 months
Vascular disease, or bleeding problems
Brain cancer
Major Surgical Procedure within 28 days prior to start date
Minor surgical procedures within 7 days prior to start date
Pregnant or lactating
Abdominal or bowel problems like bleeding
History of abdominal fistula, GI perforation or Intra-abdominal abscess
Serious, non-healing wound, ulcer or bone fracture
Acute hepatitis
Active infections requiring antibiotics
Inability to comply with study or follow up procedures

Study is for people with:

Ovarian Cancer

Phase:

Phase 2

Estimated Enrollment:

45

Study ID:

NCT00267696

Recruitment Status:

Completed

Sponsor:

Ohio State University Comprehensive Cancer Center

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There is 1 Location for this study

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The Ohio State University & James Cancer Hospital
Columbus Ohio, 43210, United States

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Study is for people with:

Ovarian Cancer

Phase:

Phase 2

Estimated Enrollment:

45

Study ID:

NCT00267696

Recruitment Status:

Completed

Sponsor:


Ohio State University Comprehensive Cancer Center

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