Ovarian Cancer Clinical Trial
Study of Oral ENMD-2076 Administered to Patients With Ovarian Cancer
Summary
The purpose of this study is to determine whether oral ENMD-2076 is effective in treatment of patients with platinum resistant ovarian, fallopian, or peritoneal cancer. Additional sites to be added.
Eligibility Criteria
Inclusion Criteria:
Have histologically documented diagnosis of ovarian, fallopian or peritoneal cancer that is platinum resistant.
Have a pre-study echocardiogram or multigated acquisition (MUGA) scan with an actual left ventricular ejection fraction of greater than or equal to the institution lower limit of normal
Greater than or equal to 18 years of age
Have clinically acceptable laboratory screening results
Have an ECOG performance status of 0 or 1
Able to tolerate oral medications
Exclusion Criteria:
Have uncontrolled hypertension (systolic blood pressure greater than 150mmHg or diastolic blood pressure greater than 100mmHg); require two or more antihypertensive medications to control hypertension (including ACE inhibitors, beta blockers, calcium channel blockers, or diuretics)
Have chronic atrial fibrillation or QTc interval corrected for heart rate of greater than 470 msec
Have active, acute, or chronic clinically significant infections or bleeding
Have persistent 2+ protein by urinalysis or a history of nephrotic syndrome
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There are 4 Locations for this study
Aurora Colorado, 80045, United States
Chicago Illinois, 60637, United States
Indianapolis Indiana, 46202, United States
Boston Massachusetts, 02115, United States
New York New York, , United States
Toronto Ontario, , Canada
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