Weekly Topotecan Therapy in Patients With Ovarian Cancer

Inclusion Criteria:

Patients must have a histopathologic diagnosis of epithelial ovarian cancer.
Patients must have completed front-line chemotherapy and be clinically NED (CA 125 <35, negative CT scan, negative physical exam).
Patients may have a second look laparoscopy, however, there must be no gross disease present (microscopic disease or pathologically negative).
Patients must not have had other myelosuppressive therapy within four weeks of initiating topotecan therapy.
Topotecan treatment must begin within 10 weeks following last cycle of initial chemotherapy.
Patients may have had only one prior chemotherapy regimen.

Exclusion Criteria:

Patients with a concomitant malignancy other than squamous cell or basal cell skin cancer.
Patients who are pregnant or breast-feeding.