A Study of BMS-986218 or BMS-986218 Plus Nivolumab in Combination With Docetaxel in Participants With Metastatic Castration-resistant Prostate Cancer Summary The purpose of this study is to assess the safety, efficacy, tolerability, and toxicity of docetaxel alone, in combination with BMS-986218, or in combination with nivolumab plus BMS-986218 in men who have metastatic castration-resistant prostate cancer (mCRPC) that progressed after novel antiandrogen therapy and have not received chemotherapy for mCRPC.
View Eligibility Criteria Eligibility Criteria Inclusion Criteria: Histologic confirmation of carcinoma of the prostate without small cell features Documented prostate cancer progression by Prostate Cancer Working Group 3 (PCWG3) criteria while castrate Evidence of metastatic disease documented by either bone lesions on radionuclide bone scan and/or soft tissue lesions on computed tomography (CT)/magnetic resonance imaging (MRI) Eastern Cooperative Oncology Group (ECOG) performance status 0 to 1 Ongoing androgen deprivation therapy (ADT) with a gonadotropin-releasing hormone (GnRH) agonist/antagonist or bilateral orchiectomy (i.e., surgical or medical castration) confirmed by testosterone level ≤ 1.73 nmol/L (50 ng/dL) at the screening visit Chemotherapy-naive for metastatic castration-resistant prostate cancer (mCRPC) and have received at least one novel antiandrogen therapy (NAT) Exclusion Criteria: Concurrent malignancy (present during screening) requiring treatment or history of prior malignancy active within 2 years prior to treatment assignment in Part 1 or randomization in Part 2 Untreated central nervous system (CNS) metastases Leptomeningeal metastases Active, known or suspected autoimmune disease Other protocol-defined inclusion/exclusion criteria apply
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There are 80 Locations for this study
Arizona Oncology - Tucson - Wilmot Road Location Tucson Arizona, 85711, United States
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Local Institution Los Angeles California, 90027, United States
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Rocky Mountain Cancer Centers - Littleton Littleton Colorado, 80120, United States
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Local Institution New Haven Connecticut, 06510, United States
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Medical Oncology Hematology Consultants - Newark Newark Delaware, 19713, United States
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Florida Urology Partners, LLP - Tampa Tampa Florida, 33609, United States
Local Institution Atlanta Georgia, 30322, United States
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Northwest Georgia Oncology Centers PC Marietta Georgia, 30060, United States
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Local Institution Chicago Illinois, 60637, United States
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Local Institution Baltimore Maryland, 21287, United States
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Maryland Oncology Hematology, P.A. Columbia Maryland, 21044, United States
Local Institution Saint Louis Missouri, 63110, United States
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Columbia University Medical Center - Herbert Irving Pavilion Location New York New York, 10032, United States
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Local Institution Cary North Carolina, 27518, United States
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Oncology Hematology Care, Inc. - Eastgate Cincinnati Ohio, 45245, United States
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Willamette Valley Cancer Institute And Research Center Eugene Oregon, 97401, United States
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Thomas Jefferson University Hospital Philadelphia Pennsylvania, 19107, United States
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Texas Oncology-Beaumont Mamie McFaddin Ward Cancer Center Beaumont Texas, 77702, United States
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Texas Oncology Bedford Texas, 76022, United States
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Texas Oncology - Denton North Denton Texas, 76201, United States
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Texas Oncology Flower Mound Texas, 75028, United States
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Texas Oncology - Fort Worth Cancer Center Fort Worth Texas, 76132, United States
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The University of Texas - MD Anderson Cancer Center - Genitourinary (GU) Cancer Center Houston Texas, 77030, United States
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Local Institution McKinney Texas, 75071, United States
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Texas Oncology- Tyler Tyler Texas, 75702, United States
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Local Institution Hampton Virginia, 23666, United States
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Local Institution Milwaukee Wisconsin, 53226, United States
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Local Institution Ciudad de Buenos Aires Buenos Aires, C1417, Argentina
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Local Institution Mar Del Plata Buenos Aires, 7600, Argentina
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Local Institution - 0070 Pergamino Buenos Aires, 2700, Argentina
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Local Institution Buenos Aires , 1426, Argentina
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Local Institution - 0018 Buenos Aires , C1181, Argentina
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Local Institution Buenos Aires , C1426, Argentina
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Local Institution - 0025 Tucuman , 4000, Argentina
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Local Institution Darlinghurst New South Wales, 2010, Australia
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Local Institution - 0066 Elizabeth Vale South Australia, 5112, Australia
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Local Institution Heidleberg Victoria, 3084, Australia
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Local Institution Hamilton Ontario, L8V 5, Canada
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Local Institution Toronto Ontario, M5G 2, Canada
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Local Institution Quebec , G1R 2, Canada
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Local Institution Nice Paca, 06189, France
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Local Institution Besançon , 25030, France
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Local Institution Bordeaux , 33076, France
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Local Institution Brest , 29609, France
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Local Institution Clermont-Ferrand , 63003, France
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Local Institution - 0008 Lyon , 69008, France
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Local Institution - 0076 Marseille , 13009, France
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Local Institution Saint-Quentin , 02321, France
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Local Institution Toulouse , 31100, France
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Local Institution - 0014 Villejuif Cedex , 94800, France
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Local Institution - 0010 Athens I, 115 2, Greece
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Local Institution - 0007 Athina I, 115 2, Greece
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Local Institution - 0054 Marousi I, 151 2, Greece
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Local Institution - 0032 Peiraias I, 185 4, Greece
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Local Institution Athens , 155 6, Greece
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Local Institution Pylaia-Chortiatis , 57001, Greece
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Local Institution - 0069 Thessaloniki , 54645, Greece
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Local Institution Thessaloniki , 56403, Greece
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Local Institution - 0021 Rozzano MI, 20089, Italy
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Local Institution Meldola , 47014, Italy
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Local Institution - 0037 Milano , 20162, Italy
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Local Institution - 0016 Modena , 41124, Italy
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Local Institution - 0029 Pozzuoli , 80078, Italy
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Local Institution Roma , 00152, Italy
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Local Institution - 0074 Dordrecht ZH, 3318 , Netherlands
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Local Institution Rotterdam , 3015 , Netherlands
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Local Institution Rotterdam , 3045 , Netherlands
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Local Institution Badajoz , 06006, Spain
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Local Institution Madrid , 28040, Spain
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Local Institution Santander , 39008, Spain
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Local Institution - 0075 Brighton BNH, BN2 5, United Kingdom
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Local Institution - 0064 Blackburn LAN, BB2 3, United Kingdom
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Local Institution - 0030 Preston LAN, PR2 9, United Kingdom
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Local Institution - 0073 West Midlands WLV, WV10 , United Kingdom
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Local Institution - 0065 Bristol , BS2 8, United Kingdom
Local Institution Guildford , GU2 7, United Kingdom
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Local Institution Huddersfield , HD3 3, United Kingdom
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Local Institution London , SM2 5, United Kingdom
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Local Institution London , W6 8R, United Kingdom
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Local Institution Torquay , TQ2 7, United Kingdom
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Local Institution - 0063 Truro , TR1 3, United Kingdom
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