A Study to Determine the Preferred Dose of the Drug, Lisinopril, for Preventing Urinary Toxicity Following Radiotherapy for Prostate Cancer

Inclusion Criteria:

Have a confirmed diagnosis of adenocarcinoma of the prostate and are candidates for curative-intent external beam radiation (with or without androgen deprivation therapy, ADT) at the Wilmot Cancer Institute Department of Radiation Oncology. Radiotherapy may be either primary, adjuvant or salvage. It may be part of combined treatment with androgen deprivation therapy.
Be stage M0 based on the standard of care staging imaging
Be able to read English
Have the psychological ability and general health that permits completion of the study requirements and required follow up
Be ≥18 and < 70 years of age
Have ECOG performance status of 0 to 2 within 180 days prior to enrollment
Have adequate renal function with creatinine clearance > 30 mL/min within 30 days prior to registration
Have hematologic and hepatic function deemed adequate for planned treatment by the treating investigator within 90 days prior to registration, including:
hemoglobin ≥9.0 g/dL, independent of transfusion and/or growth factors
platelet count ≥100,000/µL independent of transfusion and/or growth factors
Have a baseline systolic blood pressure of >130.

Exclusion Criteria:

Have received prior pelvic radiotherapy
Be taking lisinopril or other RAS modifying drug within two months prior to registration
Have had a prior allergic reaction to lisinopril