Androgen Deprivation Therapy and Vorinostat Followed by Radical Prostatectomy in Treating Patients With Localized Prostate Cancer

Inclusion Criteria:

Histologic documentation of prostatic adenocarcinoma in 3 or more biopsy cores, of which at least 1 core demonstrates > 30% involvement with tumor; confirmation of localized disease by magnetic resonance imaging (MRI) with endorectal probe if available

No evidence of distant disease on a:

Computed tomography (CT) or MRI of the abdomen and pelvis
Radionuclide bone scan (with plain film or MRI confirmation as clinically indicated)

Appropriate candidate for radical prostatectomy

Adequate cardiac function (evidence of cardiac disease should be evaluated to determine appropriateness of patient as a surgical candidate)
Candidates may have a history of deep vein thrombosis, pulmonary embolism, and/or cerebrovascular accident, or require concomitant systemic anticoagulation, if otherwise deemed to be suitable for radical prostatectomy
White blood cell (WBC) > 3000/uL
Platelets > 150,000/uL
Creatinine < 2 mg/dL
Serum PSA < 100 ng/mL
Bilirubin < 1.5 X ULN (institutional upper limits of normal)
Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) < 2 X ULN
Karnofsky performance status > 70%
Willingness to undergo pretreatment transrectal ultrasound-guided prostate needle biopsy (optional)
Willingness to use adequate contraceptive methods during study therapy and for at least 3 months after completion of therapy
Ability to understand and willingness to sign a written informed consent document

Exclusion Criteria:

Evidence of small-cell, transitional-cell, or neuroendocrine pathologic features

Prior hormonal therapy with (e.g. 5-alpha-reductase inhibitors, gonadotropin hormone releasing analogs, steroids, megestrol acetate, or nonstudy-related antiandrogens), chemotherapy, or herbal medications administered with the intent to treat the patient's malignancy

Patients on valproic acid (a histone-deacetylase inhibitor) to treat prostate cancer are not eligible
History of allergic reactions attributed to compounds of similar chemical or biological composition to vorinostat
Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situation that would compromise compliance with study requirements
Currently active secondary malignancy (as determined by the treating physician) other than non-melanoma skin cancer