This study will test the hypothesis that a low-carbohydrate Atkins diet will prevent or at least minimize the metabolic consequences of androgen deprivation therapy (ADT).
Androgen deprivation therapy (ADT) is the standard treatment for advanced prostate cancer. While a very effective anti-cancer treatment, ADT is associated with significant toxicity including but not limited to major metabolic disturbances including impaired glucose tolerance, insulin resistance, and weight gain. We hypothesize that limiting carbohydrates within the diet will prevent or at least minimize these consequences.
Histologically confirmed adenocarcinoma of the prostate Scheduled to initiate ADT with an anticipated duration of ≥ 6 months Overweight or obese (body mass index ≥ 25 kg/m2)
Exclusion Criteria:
Symptomatic metastatic disease Myocardial infarction within 6 months Treatment with medications known to affect insulin or glucose levels (i.e. insulin, oral hypoglycemics, prednisone, etc.) Patient consuming a low-carbohydrate diet Medical conditions or co-morbidities that preclude participation in the protocol Vegetarians
