Bevacizumab With Hormonal and Radiotherapy for High-Risk Prostate Cancer

Inclusion Criteria:

High Risk Prostate Cancer as defined as ONE of the following:

Clinical T2b-T4
Gleason sum score 8-10
PSA more than 20 and Gleason sum score 7
In addition, clinical T2a patients are eligible if 5 or more biopsies contain Gleason 4+3 cancer (minimum of 10 biopsies total required)
No evidence of metastatic disease within 60 days of enrollment, confirmed by physical examination, chest x-ray, bone scan, and computed tomography of the abdomen and pelvis
ECOG performance status of 0, 1 or 2

Exclusion Criteria:

Concurrent or prior treatment with radiation, cytotoxic, biologic therapy for prostate cancer; any major surgery within four weeks, prior hormonal therapy (except finasteride for obstructive voiding symptoms)
Major surgical procedure, open biopsy, or significant traumatic injury within 28 days prior to Day 0, anticipation of need for major surgical procedure during the course of the study; Minor surgical procedures such as fine needle aspirations or core biopsies within 7 days prior to Day 0
Presence of central nervous system or brain metastases
Blood pressure of >150/100 mmHg
History of myocardial infarction within 6 months
History of stroke within 6 months
Current, recent (within 4 weeks of the first infusion of this study), or planned participation in an experimental drug study other than a Genentech-sponsored bevacizumab cancer study