Carboplatin, Everolimus, and Prednisone in Treating Patients With Metastatic Prostate Cancer That Progressed After Docetaxel

DISEASE CHARACTERISTICS:

Histologically confirmed metastatic adenocarcinoma of the prostate
Objective disease progression or rising PSA despite androgen deprivation therapy and antiandrogen withdrawal (when applicable)

Progressed after ≥ 1 prior docetaxel-based chemotherapy regimen for metastatic disease

Patients with measurable disease* must have either rising PSA, increase in size of the lesion(s), or both

Patients with rising PSA as the only evidence of disease progression must demonstrate a rising trend with 2 successive elevations ≥ 1 week apart
Patients with no measurable disease must have a PSA ≥ 5 ng/mL or new areas of bony metastases on bone scan NOTE: *There is no minimum PSA requirement for patients with measurable disease

Documented to be castrate with a testosterone level of ≤ 0.5 ng/mL

Leuteinizing hormone-releasing hormone agonist therapy must be continued, if required to maintain castrate levels of testosterone
No uncontrolled brain or leptomeningeal metastases, including patients who continue to require glucocorticoids for brain or leptomeningeal metastases

PATIENT CHARACTERISTICS:

Zubrod performance status 0-1
ANC ≥ 1,500/mm^3
Hemoglobin ≥ 9.0 g/dL
Platelet count ≥ 100,000/mm^3
Total bilirubin ≤ 1.5 times upper limit of normal (ULN)
Calculated creatinine clearance ≥ 50 mL/min OR serum creatinine ≤ 2 mg/dL
AST and/or ALT ≤ 2.5 times ULN if alkaline phosphatase normal OR alkaline phosphatase ≤ 4 times ULN if AST and/or ALT normal (for patients without documented bone metastases or for patients with liver metastases)
AST and/or ALT < 2.5 times ULN, without regard to alkaline phosphatase levels (for patients with documented bone metastases)
Fasting serum cholesterol ≤ 300 mg/dL OR ≤ 7.75 mmol/L AND fasting triglycerides ≤ 2.5 times ULN (in the case that one or both of these thresholds are exceeded, the patient is eligible only after initiation of appropriate lipid-lowering medication)
Fertile patients must use effective contraception during and for ≥ 6 months after completion of study treatment
Willing and able to comply with this study
Able to ingest oral medication
No other malignancies except non-melanoma skin cancer or any other adequately treated cancer in complete remission for ≥ 2 years
No significant traumatic injury within the past 4 weeks
No active (acute or chronic) or uncontrolled severe infections

No severe and/or uncontrolled medical conditions or other conditions that could affect study participation, including the following:

NYHA class III-IV symptomatic congestive heart failure
Unstable angina pectoris, symptomatic congestive heart failure, myocardial infarction within the past 6 months, serious uncontrolled cardiac arrhythmia, or any other clinically significant cardiac disease
Severely impaired lung function as defined by spirometry and DLCO that is 50% of the normal predicted value and/or oxygen saturation that is ≤ 88% at rest on room air
Uncontrolled diabetes as defined by fasting serum glucose > 1.5 times ULN
Liver disease such as cirrhosis, chronic active hepatitis, or chronic persistent hepatitis
Known history of HIV seropositivity, hepatitis B or C
Impairment of gastrointestinal (GI) function or GI disease that may significantly alter the absorption of everolimus (e.g., ulcerative disease, uncontrolled nausea, vomiting, diarrhea, malabsorption syndrome, or small bowel resection)
Active, bleeding diathesis
No known hypersensitivity to everolimus or other rapamycins (sirolimus, temsirolimus) or to their excipients
No history of noncompliance to medical regimens
No uncontrolled diabetes mellitus

PRIOR CONCURRENT THERAPY:

See Disease Characteristics

At least 1 prior docetaxel based regimen for metastatic disease

Docetaxel based combination therapy or docetaxel alone considered as 1 regimen
No more than 2 prior chemotherapy regimens for metastatic disease
No prior treatment with an mTOR inhibitor (sirolimus, temsirolimus, everolimus)
At least 6 weeks since prior bicalutamide or nilutamide
At least 4 weeks since prior flutamide
More than 4 weeks since prior and no other concurrent investigational drugs
More than 4 weeks since prior and no other concurrent anticancer therapies (including chemotherapy, radiotherapy, or antibody-based therapy)
More than 4 weeks since prior and no concurrent major surgery (defined as requiring general anesthesia) and recovered
More than 1 week since prior and no concurrent immunization with attenuated live vaccines

No concurrent chronic, systemic treatment with corticosteroids or other immunosuppressive agents

Topical or inhaled corticosteroids are allowed
No concurrent prophylactic growth factors
Concurrent bisphosphonate therapy allowed