Prostate Cancer Clinical Trial

Diffusion-Weighted MRI in Staging Patients With Localized Prostate Cancer

Summary

This pilot clinical trial studies how well diffusion-weighted magnetic resonance imaging (MRI) works in staging patients with prostate cancer that has not spread to nearby lymph nodes or other parts of the body. New imaging techniques, such as diffusion-weighted MRI, may be a less invasive way of predicting the stage and grade of prostate cancer.

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Full Description

PRIMARY OBJECTIVES:

I. To determine the sensitivity and specificity of diffusion-weighted MRI for pathologic T3 stage prostate cancer using a 3 Tesla (3T) magnet with a surface coil.

OUTLINE:

Patients undergo diffusion-weighted MRI of the pelvis.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Biopsy-documented adenocarcinoma of the prostate which is intermediate or high risk, defined as possessing one or more of the following features:

Gleason >= 7
> 50% biopsy cores +
Prostate-specific antigen (PSA) >= 10
Interested in undergoing a radical prostatectomy as definitive management for prostate cancer

No clinical or radiographic evidence for distant metastatic disease

In subjects with PSA < 20 no radiographic staging is required in the absence of clinical symptoms for distant metastatic disease; for those with PSA > 20, a bone scan must document lack of concern for bone involvement

Exclusion Criteria:

Ineligible for surgery due to cardiac, pulmonary, or other major comorbidity factor
History of claustrophobia
Pacemaker or other implanted metal objects which would make subject ineligible for MRI, per standard criteria
Unable to give written informed consent

Study is for people with:

Prostate Cancer

Estimated Enrollment:

9

Study ID:

NCT02237612

Recruitment Status:

Completed

Sponsor:

University of Southern California

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There is 1 Location for this study

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USC Norris Comprehensive Cancer Center
Los Angeles California, 90033, United States

How clear is this clinincal trial information?

Study is for people with:

Prostate Cancer

Estimated Enrollment:

9

Study ID:

NCT02237612

Recruitment Status:

Completed

Sponsor:


University of Southern California

How clear is this clinincal trial information?

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