Diffusion-Weighted MRI in Staging Patients With Localized Prostate Cancer

Inclusion Criteria:

Biopsy-documented adenocarcinoma of the prostate which is intermediate or high risk, defined as possessing one or more of the following features:

Gleason >= 7
> 50% biopsy cores +
Prostate-specific antigen (PSA) >= 10
Interested in undergoing a radical prostatectomy as definitive management for prostate cancer

No clinical or radiographic evidence for distant metastatic disease

In subjects with PSA < 20 no radiographic staging is required in the absence of clinical symptoms for distant metastatic disease; for those with PSA > 20, a bone scan must document lack of concern for bone involvement

Exclusion Criteria:

Ineligible for surgery due to cardiac, pulmonary, or other major comorbidity factor
History of claustrophobia
Pacemaker or other implanted metal objects which would make subject ineligible for MRI, per standard criteria
Unable to give written informed consent