Prostate Cancer Clinical Trial
Early Prostate Cancer: Predicting Treatment Response
Summary
This study will replicate/validate the risk prediction model developed for the Comparative Effectiveness Analysis of Surgery and Radiation (CEASAR) study in a more diverse patient population to assess generalizability of the model as well as evaluate the relative contribution of the Decipher Prostate Cancer Test and ProstateNext Test from Ambry Genetics, to the risk prediction model for estimating treatment outcomes, and thereby improve personalization of treatment options.
Full Description
The study will contribute a replicable model for improving risk prediction from patient characteristics, clinical severity indicators, and genomic tests to aid in personalizing treatment. The proposed registry would also allow future comparisons of the gene expression used in other competing commercial test. The addition of the suggested genomic classifier and its associations with other patient and clinical characteristics will enhance the ability of future studies, analogous to CEASAR, to accurately predict the risk of tumor aggressiveness in prostate cancer.
Eligibility Criteria
Inclusion Criteria:
18 - 90 years of age
Prostate-Specific Antigen (PSA) values <50ng/ml
Clinical stage of T1 or T2
No evidence of metastasis or nodal involvement
Exclusion Criteria:
Age 91 or greater
Clinically locally advanced or metastatic disease
PSA equal to or greater than 50ng/ml
Diagnosis of malignancy (excluding squamous or basal cell carcinoma of the skin) within 3 years of diagnosis of prostate cancer
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There are 5 Locations for this study
Irvine California, 92697, United States
Long Beach California, 90822, United States
Los Angeles California, 90048, United States
Los Angeles California, 90095, United States
West Los Angeles California, 90073, United States
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