Prostate Cancer Clinical Trial
Effect of Lap-Band Induced Weight Loss on Serum PSA Levels
Summary
The proposed prospective study aims to determine whether interpretation of PSA levels in morbidly obese men require correction due to the obesity itself. If PSA levels are found to rise after weight loss, interpretation of PSA levels in morbidly obese men may be improved by upward correction of the PSA level. A 'correction factor' may be proposed for the interpretation of PSA levels in obese men, toward the clinical decision regarding indication for prostate biopsy.
Full Description
The main objective of this study is to determine whether interpretation of PSA levels in morbidly obese men require correction due to the obesity itself. Secondary outcome measures that will be followed include the affect of obesity and weight loss on testosterone, estradiol and leptin. In as much as these might also affect PSA, we will be measuring these values as well. Also, we do not know the effects of lap-band induced weight loss on clinical outcome measures of sexual, bowel and urinary function. Thus we will aim to investigate these parameters as well.
Eligibility Criteria
Inclusion Criteria:
obese men undergoing lap-band surgery
Exclusion Criteria:
prior diagnosis of prostate cancer
prior prostate surgery
use of 5-alpha reductase inhibitors
history of prostatitis
recurrent Urinary Tract Infection (UTI).
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There is 1 Location for this study
Brooklyn New York, 11219, United States
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