Enzalutamide and Hormone Therapy Before, During, and After Radiation for High Risk Localized Prostate Cancer

Inclusion Criteria:

histologically proven adenocarcinoma of the prostate within 6 months of screening
Eastern Cooperative Oncology Group(ECOG) score 0-2
adequate organ and and blood marrow function
must be a candidate for long-term androgen deprivation in combination with external beam radiation for the treatment of high risk prostate cancer
patient must permit a targeted prostate biopsy at the time of study initiation or at the beginning of radiation treatment
men who are sexually active with female partners of child-bearing potential mush agree to use adequate contraception

Exclusion Criteria:

prior treatment with agents known to have endocrine effects on prostate cancer
treatment with corticosteroids within 4 weeks of enrollment
treatment with androgens within 6 months of enrollment
may not be receiving any other investigational agents
Prostate specific antigen greater than 160ng/dL
history of malignancy( other than non-melanoma skin cancer) within 5 years
uncontrolled intercurrent illness
cardiovascular event within 6 months of enrollment
seizure or seizure disorder history
contraindications to MRI- pacemakers, clips, etc