Prostate Cancer Clinical Trial

F18 DCFPyL PET/CT in Imaging Participants With Recurrent Prostate Cancer

Summary

This study provides fluorine F 18 DCFPyL positron emission tomography/computed tomography (PET/CT) to participants with prostate cancer that has come back. Diagnostic procedures, such as fluorine F 18 DCFPyL PET/CT, may help find and diagnose prostate cancer and find out how far the disease has spread.

View Full Description

Full Description

PRIMARY OBJECTIVES:

I. To evaluate fluorine F 18 DCFPyL (18F-DCFPyL) PET/CT for detection of recurrent prostate cancer after initial therapy in patients with elevated prostate-specific antigen (PSA).

OUTLINE:

Participants receive fluorine F 18 DCFPyL intravenously (IV). After 60-120 minutes, participants undergo whole body PET/CT. Immediately after the first scan, participants may undergo a second PET/CT without receiving fluorine F 18 DCFPyL.

After completion of study, participants are followed up at 24-72 hours.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Biopsy proven prostate adenocarcinoma

Rising PSA after definitive therapy with prostatectomy or radiation therapy (external beam or brachytherapy)

Post radical prostatectomy (RP) - American Urological Association (AUA) recommendation

PSA greater than 0.2 ng/mL measured after at least 6 weeks from radical prostatectomy
Confirmatory persistent PSA greater than 0.2 ng/mL (total of two PSA measurements greater than 0.2 ng/mL)

Post-radiation therapy - American Society for Radiation Oncology (ASTRO) - Phoenix consensus definition

A rise of PSA measurement of 2 or more ng/mL over the nadir
Able to provide written consent
Karnofsky performance status of > 50 (or Eastern Cooperative Oncology Group [ECOG] / World Health Organization [WHO] equivalent)

Exclusion Criteria:

Unable to provide informed consent
Inability to lie still for the entire imaging time
Inability to complete the needed investigational and standard-of-care imaging examinations due to other reasons (severe claustrophobia, radiation phobia, etc.)
Any additional medical condition, serious intercurrent illness, or other extenuating circumstance that, in the opinion of the Investigator, may significantly interfere with study compliance

Study is for people with:

Prostate Cancer

Study ID:

NCT03501940

Recruitment Status:

No longer available

Sponsor:

Andrei Iagaru

Check Your Eligibility

Let’s see if you might be eligible for this study.

What is your age and gender ?

Submit

There is 1 Location for this study

See Locations Near You

Stanford Cancer Institute Palo Alto
Palo Alto California, 94304, United States

How clear is this clinincal trial information?

Study is for people with:

Prostate Cancer

Study ID:

NCT03501940

Recruitment Status:

No longer available

Sponsor:


Andrei Iagaru

How clear is this clinincal trial information?

×

Introducing, the Journey Bar

Use this bar to access information about the steps in your cancer journey.

Please confirm you are a US based health care provider:

Yes, I am a health care Provider No, I am not a health care provider