Prostate Cancer Clinical Trial
Feasibility Study of Prostate Tumor Localization for Focal Cryoablation of Prostate Carcinoma
Summary
The purpose of the present study is to find out if MRI techniques examining (1) the motion of water molecules in the prostate (diffusion sensitive MRI), (2) the difference in blood flow to the prostate (dynamic contrast enhanced MRI), and (3) differences in chemical composition of the prostate (MR spectroscopy), can be used to detect prostate cancer early and non-invasively. Localization of the cancer within the prostate would be of particular importance in focal cryoablation of prostate carcinoma which we hope to improve as a result of this project.
Additional aim of the study is to correlate expression of genes believed to pay a role in prostate cancer with MRI findings.
Full Description
Radical prostatectomy patients will undergo an MRI prior to their scheduled surgery. Ex vivo imaging will be done on prostates once removed. Results from the final pathology with be compared with results of imaging to determine the accuracy of the image analysis in cancer localization and staging.
Brachytherapy patients will undergo an MRI prior to their scheduled procedure. Two areas of suspected cancer and two areas without suspected cancer will be prospectively identified based on the MRI imaging. At the time of brachytherapy, transrectal needle biopsies will be obtained from the previously identified areas. The needle cores will be reviewed by study pathologist to determine the accuracy of the image analysis in cancer localization and staging.
Eligibility Criteria
Inclusion Criteria:
patients who have been diagnosed with prostate cancer and are scheduled for radical prostatectomy or for brachytherapy
patients who have not received any preoperative treatment for their diagnosis of prostate cancer
Exclusion Criteria:
patients with implants that are electronically, magnetically, or mechanically active
patients with intracranial aneurysm clips
patients who have undergone cosmetic eyelid surgery
patients with history of pheochromocytoma, insulinoma and acute glaucoma
patients with estimated glomerular filtration rate (eGFR) less than 60 ml/min/1.73m2
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There is 1 Location for this study
Saint Louis Missouri, 63110, United States
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