Home-based Exercise Intervention for Patients With Metastatic Prostate Cancer

Inclusion Criteria:

Metastatic disease that has progressed despite castrate levels of testosterone (surgically or medically castrated, with testosterone levels of < 50 ng/dL) receiving ADT. This will be verified by assessing total testosterone levels within 4 weeks prior to enrollment.
No current chemotherapy.
Patients may be receiving additional hormonal therapy agents including but not limited to antiandrogens (e.g. bicalutamide, enzalutamide) and CYP17 inhibitors (e.g. abiraterone).
Ability to engage safely in moderate exercise as determined by their treating physician.
Not previously engaged in regular exercise training (<3 or more d/wk for > 30 min/d or <90 mins per week total including strength training, aerobic training, or walking) in the past 6 months.
Access to a computer or a smart phone for syncing and uploading wearable activity data.
Be able to speak and read English.

Exclusion Criteria:

Any condition that causes severe pain with exertion.
History of bone fractures.

Active cardiovascular disease including any of the following:

New York Heart Association (NYHA) Grade II or greater congestive heart failure .
History of myocardial infarction or unstable angina within 6 months prior to Day 1.
History of stroke or transient ischemic attack within 6 months prior to Day 1.
Acute or chronic respiratory disease that is severe enough to compromise the ability of the participant to safely engage in exercise training protocol.
Acute or chronic bone/joint/muscular abnormalities compromising their ability to exercise.
Neurological conditions that affect balance and, or muscle strength.
Dementia, altered mental status or any psychiatric condition prohibiting the understanding or rendering of informed consent.