Prostate Cancer Clinical Trial
Multiparametric MRI in Evaluating Cancer Stage and Helping Treatment Planning in Patients With Prostate Cancer
Summary
This phase II trial studies how well multiparametric magnetic resonance imaging (MRI) works in evaluating cancer stage and helping treatment planning in patients with prostate cancer. Multiparametric MRI may be useful for evaluating the type of cancer in finding aggressive disease.
Full Description
PRIMARY OBJECTIVES:
I. To estimate the diagnostic performance as quantified by the area under the ROC curve to detect aggressive prostate cancer.
II. To develop a risk prediction model by incorporating overall PI-RADS, PSA, Gleason score and clinical stage to predict the presence of aggressive prostate cancer.
SECONDARY OBJECTIVES:
I. To evaluate the diagnostic performance of the individual PI-RADS score of each MRI parameter (T2W, DWI and DCE), as determined by local imaging review.
TERTIARY OBJECTIVES:
I. All clinical data including magnetic resonance (MR) images will be banked for future exploratory research aims.
OUTLINE:
Patients undergo mpMRI within 3 months prior to schedule surgery.
After completion of study, patients are followed up until radical prostatectomy pathology is reported and finalized.
Eligibility Criteria
Inclusion Criteria:
Recently diagnosed with prostate cancer for whom definitive surgical treatment is indicated
Exclusion Criteria:
Not suitable to undergo MRI or receive gadolinium-based contrast agent (severe, untreatable claustrophobia; MRI-incompatible metallic objects or implanted medical devices; renal failure; weight greater than allowable by scanner per institutional standard practice)
Prior surgical and/or non-surgical treatment for prostate cancer
Prior hip replacement or other major pelvic surgery
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There are 39 Locations for this study
Phoenix Arizona, 85054, United States
Scottsdale Arizona, 85259, United States More Info
Principal Investigator
New Haven Connecticut, 06520, United States
Jacksonville Florida, 32209, United States More Info
Principal Investigator
Jacksonville Florida, 32224, United States More Info
Principal Investigator
'Aiea Hawaii, 96701, United States
'Aiea Hawaii, 96701, United States
Honolulu Hawaii, 96813, United States
Honolulu Hawaii, 96813, United States
Zion Illinois, 60099, United States
Indianapolis Indiana, 46202, United States More Info
Principal Investigator
Iowa City Iowa, 52242, United States More Info
Principal Investigator
Kansas City Kansas, 66160, United States More Info
Principal Investigator
Overland Park Kansas, 66211, United States More Info
Principal Investigator
Metairie Louisiana, 70006, United States More Info
Principal Investigator
Metairie Louisiana, 70006, United States More Info
Principal Investigator
Boston Massachusetts, 02115, United States
Detroit Michigan, 48202, United States More Info
Principal Investigator
Grand Rapids Michigan, 49503, United States More Info
Principal Investigator
West Bloomfield Michigan, 48322, United States More Info
Principal Investigator
Rochester Minnesota, 55905, United States More Info
Principal Investigator
Saint Louis Missouri, 63110, United States
Saint Louis Missouri, 63141, United States More Info
Principal Investigator
Lebanon New Hampshire, 03756, United States More Info
Principal Investigator
New York New York, 10065, United States More Info
Principal Investigator
Stony Brook New York, 11794, United States
Chapel Hill North Carolina, 27599, United States More Info
Principal Investigator
Medford Oregon, 97504, United States More Info
Principal Investigator
Hershey Pennsylvania, 17033, United States More Info
Principal Investigator
Philadelphia Pennsylvania, 19104, United States More Info
Principal Investigator
Philadelphia Pennsylvania, 19107, United States
Philadelphia Pennsylvania, 19111, United States More Info
Principal Investigator
Nashville Tennessee, 37232, United States More Info
Principal Investigator
Conroe Texas, 77384, United States More Info
Principal Investigator
Dallas Texas, 75390, United States More Info
Principal Investigator
Houston Texas, 77030, United States More Info
Principal Investigator
Houston Texas, 77079, United States More Info
Principal Investigator
League City Texas, 77573, United States More Info
Principal Investigator
San Antonio Texas, 78229, United States More Info
Principal Investigator
San Antonio Texas, 78229, United States
Sugar Land Texas, 77478, United States More Info
Principal Investigator
Morgantown West Virginia, 26506, United States More Info
Principal Investigator
Waukesha Wisconsin, 53188, United States
Waukesha Wisconsin, 53188, United States More Info
Principal Investigator
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