Prostate Cancer Clinical Trial
Multiparametric MRI in Evaluating Cancer Stage and Helping Treatment Planning in Patients With Prostate Cancer
Summary
This phase II trial studies how well multiparametric magnetic resonance imaging (MRI) works in evaluating cancer stage and helping treatment planning in patients with prostate cancer. Multiparametric MRI may be useful for evaluating the type of cancer in finding aggressive disease.
Full Description
PRIMARY OBJECTIVES:
I. To estimate the diagnostic performance as quantified by the area under the ROC curve to detect aggressive prostate cancer.
II. To develop a risk prediction model by incorporating overall PI-RADS, PSA, Gleason score and clinical stage to predict the presence of aggressive prostate cancer.
SECONDARY OBJECTIVES:
I. To evaluate the diagnostic performance of the individual PI-RADS score of each MRI parameter (T2W, DWI and DCE), as determined by local imaging review.
TERTIARY OBJECTIVES:
I. All clinical data including magnetic resonance (MR) images will be banked for future exploratory research aims.
OUTLINE:
Patients undergo mpMRI within 3 months prior to schedule surgery.
After completion of study, patients are followed up until radical prostatectomy pathology is reported and finalized.
Eligibility Criteria
Inclusion Criteria:
Recently diagnosed with prostate cancer for whom definitive surgical treatment is indicated
Exclusion Criteria:
Not suitable to undergo MRI or receive gadolinium-based contrast agent (severe, untreatable claustrophobia; MRI-incompatible metallic objects or implanted medical devices; renal failure; weight greater than allowable by scanner per institutional standard practice)
Prior surgical and/or non-surgical treatment for prostate cancer
Prior hip replacement or other major pelvic surgery
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There are 39 Locations for this study
Phoenix Arizona, 85054, United States More Info
Principal Investigator
Scottsdale Arizona, 85259, United States
New Haven Connecticut, 06520, United States More Info
Principal Investigator
Jacksonville Florida, 32209, United States More Info
Principal Investigator
Jacksonville Florida, 32224, United States More Info
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'Aiea Hawaii, 96701, United States More Info
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'Aiea Hawaii, 96701, United States More Info
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Honolulu Hawaii, 96813, United States More Info
Principal Investigator
Honolulu Hawaii, 96813, United States More Info
Principal Investigator
Zion Illinois, 60099, United States
Indianapolis Indiana, 46202, United States More Info
Principal Investigator
Iowa City Iowa, 52242, United States More Info
Principal Investigator
Kansas City Kansas, 66160, United States More Info
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Overland Park Kansas, 66211, United States More Info
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Metairie Louisiana, 70006, United States More Info
Principal Investigator
Metairie Louisiana, 70006, United States More Info
Principal Investigator
Boston Massachusetts, 02115, United States More Info
Principal Investigator
Detroit Michigan, 48202, United States More Info
Principal Investigator
Grand Rapids Michigan, 49503, United States More Info
Principal Investigator
West Bloomfield Michigan, 48322, United States More Info
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Rochester Minnesota, 55905, United States More Info
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Saint Louis Missouri, 63110, United States
Saint Louis Missouri, 63141, United States More Info
Principal Investigator
Lebanon New Hampshire, 03756, United States More Info
Principal Investigator
New York New York, 10065, United States More Info
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Stony Brook New York, 11794, United States More Info
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Chapel Hill North Carolina, 27599, United States More Info
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Medford Oregon, 97504, United States More Info
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Hershey Pennsylvania, 17033, United States More Info
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Philadelphia Pennsylvania, 19104, United States More Info
Principal Investigator
Philadelphia Pennsylvania, 19107, United States More Info
Principal Investigator
Philadelphia Pennsylvania, 19111, United States More Info
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Nashville Tennessee, 37232, United States More Info
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Conroe Texas, 77384, United States More Info
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Dallas Texas, 75390, United States More Info
Principal Investigator
Houston Texas, 77030, United States More Info
Principal Investigator
Houston Texas, 77079, United States More Info
Principal Investigator
League City Texas, 77573, United States More Info
Principal Investigator
San Antonio Texas, 78229, United States More Info
Principal Investigator
San Antonio Texas, 78229, United States More Info
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Sugar Land Texas, 77478, United States More Info
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Morgantown West Virginia, 26506, United States More Info
Principal Investigator
Waukesha Wisconsin, 53188, United States
Waukesha Wisconsin, 53188, United States More Info
Principal Investigator
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