Prostate Cancer Clinical Trial
Outcomes of Focal Ablation for Prostate Cancer
Summary
This study will be designed to define the efficacy and safety of ablative therapies in the management of localized prostate cancer and comprehensively evaluate quality of life outcomes and oncologic control following treatment.
Full Description
This study will be designed to define the efficacy and safety of ablative therapies in the management of localized prostate cancer and comprehensively evaluate quality of life outcomes and oncologic control following treatment.
There are several commercially available standard of care treatments available for local therapy of the prostate. Ablative therapies may be delivered via a whole gland or focal approach by systems including cryoablation (CA), brachytherapy, irreversible electroporation (IRE), high intensity focused ultrasound (HIFU), MRI-guided transurethral ultrasound ablation (TULSA) procedure or future novel prostate ablation systems.
These are single, outpatient treatments lasting between 2-4 hours and include treatment planning and energy delivery under guidance and are either administered via transperineally approach (cryoablation, IRE, brachytherapy) or via the urethral (TULSA-Pro) or rectum (HIFU).
This study protocol will not include experimental therapy and the enrolled subjects will undergo the ablative therapy as part of their standard of care treatment.
Eligibility Criteria
Inclusion Criteria:
Men with histologically confirmed prostate adenocarcinoma diagnosed on prostate biopsy
Men with histologically confirmed local recurrence of prostate cancer diagnosed on prostate biopsy and standard of care imaging excluding locoregional or metastatic disease
Age 18-90 years.
Life expectancy > 1 year
Ability to understand and the willingness to sign a written informed consent.
Exclusion Criteria:
Anatomic abnormalities that do not allow for focal ablation
Evidence of non-organ confined disease that is not feasible for ablation
Has active urinary traction infection
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