Psoriasis Clinical Trial
24 Week Efficacy and 3-year Safety and Efficacy of Secukinumab in Active Psoriatic Arthritis
Summary
The purpose of this study is to provide 24 - 52 week efficacy, safety and tolerability data, and up to 3-year efficacy, safety and tolerability data in subjects with active Psoriatic Arthritis despite current or previous nonsteroidal anti-inflammatory drug (NSAID), disease-modifying antirheumatic drug (DMARD) therapy and/or previous anti-tumor necrosis factor alpha (TNFα) therapy.
Eligibility Criteria
Inclusion Criteria:
Diagnosis of Psoriatic Arthritis (PsA) classified by ClASsification criteria for Psoriatic ARthritis (CASPAR) criteria.
Rheumatoid factor and anti-cyclic citrullinated peptide (CCP) antibodies negative.
Diagnosis of active plaque psoriasis or nail changes consistent with psoriasis.
Inadequate control of symptoms with NSAID.
Exclusion Criteria:
Chest X-ray or chest magnetic resonance imaging (MRI) with evidence of ongoing infectious or malignant process.
Subjects taking high potency opioid analgesics.
Previous exposure to secukinumab or other biologic drug directly targeting interleukin-17 (IL-17) or IL-17 receptor.
Ongoing use of prohibited psoriasis treatments / medications.
Subjects who have ever received biologic immunomodulating agents except for those targeting TNFα.
Previous treatment with any cell-depleting therapies.
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There are 77 Locations for this study
Aventura Florida, 33180, United States
Palm Harbor Florida, 34684, United States
Sarasota Florida, 34239, United States
Indianapolis Indiana, 46256, United States
Bowling Green Kentucky, 42101, United States
Saint Louis Missouri, 63117, United States
Freehold New Jersey, 07728, United States
Albany New York, 12206, United States
Duncansville Pennsylvania, 16635, United States
Austin Texas, 78731, United States
Mesquite Texas, 75150, United States
Wenatchee Washington, 98801, United States
Kogarah New South Wales, 2217, Australia
Maroochydore Queensland, 4558, Australia
Hobart Tasmania, 7000, Australia
Malvern East Victoria, 3145, Australia
Sofia , 1413, Bulgaria
Sofia , 1431, Bulgaria
Sofia , 1505, Bulgaria
Veliko Tarnovo , 5000, Bulgaria
Victoria British Columbia, V8V 3, Canada
Winnipeg Manitoba, R3A 1, Canada
Toronto Ontario, M9W 4, Canada
Trois Rivieres Quebec, G8Z 1, Canada
Bruntal Czech Republic, 792 0, Czechia
Praha 2 Czech Republic, 128 5, Czechia
Uherske Hradiste Czech Republic, 686 0, Czechia
Aachen , 52064, Germany
Berlin , 10117, Germany
Chemnitz , 09130, Germany
Erlangen , 91056, Germany
Gommern , 39245, Germany
Hamburg , 20095, Germany
Hamburg , 22081, Germany
Hamburg , 22415, Germany
Hannover , 30625, Germany
Hildesheim , 31134, Germany
Magdeburg , 39110, Germany
Zerbst , 39261, Germany
Bologna BO, 40138, Italy
Catania CT, 95100, Italy
Genova GE, 16132, Italy
Rozzano MI, 20089, Italy
Reggio Emilia RE, 42123, Italy
Torino TO, 10128, Italy
Verona VR, 37126, Italy
Amsterdam , 1105 , Netherlands
Heerlen , 6419 , Netherlands
Rotterdam , 3079 , Netherlands
Caguas , 00725, Puerto Rico
Ponce , 00716, Puerto Rico
Chelyabinsk , 45407, Russian Federation
Ekaterinburg , 62002, Russian Federation
Moscow , 11552, Russian Federation
Rostov on Don , 34402, Russian Federation
Saratov , 41005, Russian Federation
Sestroretsk , 19770, Russian Federation
Yaroslavl , 15000, Russian Federation
Sevilla Andalucia, 41009, Spain
Santander Cantabria, 39008, Spain
Barcelona Catalunya, 08036, Spain
La Coruna Galicia, 15006, Spain
Fribourg , 1708, Switzerland
St Gallen , CH 90, Switzerland
London England, E11 1, United Kingdom
Salford Manchester, M6 8H, United Kingdom
Cannock Staffordshire, WS11 , United Kingdom
Stoke on Trent Staffordshire, ST6 7, United Kingdom
Barnsley , S75 2, United Kingdom
Eastbourne , BN21 , United Kingdom
Harrogate , HG2 7, United Kingdom
Hull , HU3 2, United Kingdom
London , NW3 2, United Kingdom
London , SE1 9, United Kingdom
Manchester , M23 9, United Kingdom
Torquay , TQ2 7, United Kingdom
Tyne And Wear , NE29 , United Kingdom
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