Psoriasis Clinical Trial
A Placebo-controlled Study With an Extension Examining the Safety and Efficacy of Alefacept in Psoriatic Arthritis
Summary
Randomized, double-blind, 24-week study of patients with psoriatic arthritis comparing alefacept + methotrexate (MTX) vs. placebo + MTX followed by a 24-week open-label extension with only alefacept + MTX treatment.
Full Description
Patients who completed the initial 24-week treatment course and met the inclusion and exclusion criteria for the 24 week open-label extension continued on their stable MTX dose and also received alefacept throughout this extension.
Eligibility Criteria
Inclusion Criteria:
Psoriatic arthritis
MTX treatment for 3 months prior to enrollment with continuing disease
Normal T-cell count
Exclusion Criteria:
Other types of psoriasis
History of malignancy or lymphoproliferative disorder
Serious infection or fever
Antibody positive for Hepatitis C, HIV or TB
Hepatic transaminases > 2X normal
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There are 27 Locations for this study
Birmingham Alabama, 35294, United States
Wheaton Maryland, 20902, United States
Lake Success New York, 11042, United States
Rochester New York, 14642, United States
Seattle Washington, 98104, United States
Victoria British Columbia, V8V 3, Canada
St Johns Newfoundland and Labrador, A1C 5, Canada
London Ontario, N6A 4, Canada
Newmarket Ontario, L3Y 3, Canada
Toronto Ontario, K1N 5, Canada
Toronto Ontario, M5T 2, Canada
Montreal Quebec, H2L 1, Canada
Berlin , D-131, Germany
Frankfurt , D-605, Germany
Goettingen , D-370, Germany
Bialystok , 15-33, Poland
Elblag , 82-30, Poland
Kalisz , 62-80, Poland
Krakow , 30-11, Poland
Torun , 87-10, Poland
Warszawa , 02-63, Poland
Moscow , 10707, Russian Federation
Moscow , 11552, Russian Federation
N. Novgorod , 60360, Russian Federation
St Petersburg , 19006, Russian Federation
St. Petersburg , 19404, Russian Federation
Yaroslavl , 15000, Russian Federation
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