Psoriasis Clinical Trial
Autoimmunity in the Pathogenesis of AF
Summary
This research study is being done to find out whether autoimmune mechanisms are associated with the development of atrial fibrillation.
Full Description
The study sets out to identify an explanation for the pathogenesis of AF, potentially forming the basis for designing novel targeted therapies to prevent or reverse this prevalent human disease. The overall objectives are to determine whether autoimmune diseases are associated with AF development and to identify specific diagnostic and prognostic biomarkers that will improve the ability to accurately predict risk of AF development. The study will prospectively enroll patients with and without AF and determine their serum cytokine levels and assess the functional responses of T cells on the basis of cytokine production after in vitro T-cell specific stimulation, using Luminex bead-based multiplex technology.
Eligibility Criteria
Inclusion Criteria:
Cases: AF (Persistent, paroxysmal AF)
Controls 1: (No prior history of AF or inflammatory or autoimmune diseases)
Controls 2: (biopsy proven Psoriasis)
Exclusion Criteria:
Clinically apparent acute infections over the past 4 weeks
Chronic infections
Recent malignancies
Recent Radiation or chemotherapy
Chronic kidney disease (≥ stage 2)
Organ transplantation
History of chronic liver disease
Major surgery or invasive procedure in the past 6 months
Internal prosthesis
Receiving immunosuppressive therapy
Known rheumatologic diseases (except for the participants with psoriasis)
Females who are known to be pregnant
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There is 1 Location for this study
Rochester Minnesota, 55905, United States
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