Clinical and Molecular Characterization of Axial Psoriatic Arthritis (PsA), A Pilot Study

Inclusion Criteria:

Persons with PsA diagnosed by a consultant Rheumatologist with disease duration of > 3 months but < 10 years with or without IBP.

Adults between the ages 18 and 80 years, with joint disease onset after 16 years of age
Patients able to understand and complete consent procedures

Study participants must have PsA, meet CASPAR criteria, and must have active disease as defined by the treating rheumatologist, including an evaluable psoriatic skin lesion amenable to 6mm punch skin biopsy.

o Psoriasis should be diagnosed by a consultant rheumatologist or dermatologist.

Study participants must have been on consistent therapy for their PsA for the past 90 days
Study participants must be naïve to biological treatment and targeted synthetic DMARD treatment (examples: JAK inhibitors, apremilast)

Exclusion Criteria:

• Persons with musculoskeletal (peripheral or axial) symptoms for >10 years

Persons with planned major surgery (e.g., joint replacement) within the duration of the collection of data for the study
Persons with a history of chemotherapy, radiation therapy or immunotherapy for cancer in the preceding 5 years.
Persons with ongoing cancer (not excluding non-melanoma skin, cervical/breast in-situ carcinoma) but those fully recovered from an episode of cancer (in remission for more than 5 years) may be included at the discretion of the patient's treating rheumatologist.
Persons with an active severe or serious infection
Patients with non-severe infection at the discretion of the Investigator
Persons with other concomitant disorders incompatible with study (at discretion of Investigator).