Psoriasis Clinical Trial
Extension Study of Secukinumab Prefilled Syringes in Subjects With Moderate to Severe Chronic Plaque-type Psoriasis Completing Preceding Psoriasis Phase III Studies With Secukinumab
Summary
This was an extension study of secukinumab prefilled syringes in subjects with moderate to severe chronic plaque-type psoriasis completing preceding psoriasis phase III studies with secukinumab. Subjects on secukinumab at the end of treatment period in phase III studies (e.g., ongoing CAIN457A2302 and CAIN457A2303 and potentially other secukinumab phase III studies) were eligible to join this extension study. This extension study was planned to collect an additional 2 years of long-term efficacy, safety, and tolerability data of secukinumab in either continuous or interrupted therapy (randomized withdrawal period) in subjects showing at least partial response to secukinumab and completing treatment period on secukinumab in previous phase III studies. In this extension study, the prefilled syringe (PFS) liquid formulation of secukinumab were used.
Eligibility Criteria
Key Inclusion Criteria:
Completed the full study treatment period of 52 weeks in preceding phase III studies, and have been receiving secukinumab treatment during the maintenance phase of the preceding phase III studies, and show at least a partial response (PASI 50 or better) at Week 52 of the preceding phase III studies.
Written informed consent form.
Key Exclusion Criteria:
A protocol deviation in either of the preceding phase III studies which according to the investigator prevented the meaningful analysis of the extension study for the individual subject.
Ongoing use of prohibited psoriasis or non-psoriasis treatments.
Pregnant or nursing (lactating) women, where pregnancy is defined as the state of a female after conception and until the termination of gestation, confirmed by a positive hCG laboratory test (>10 mIU/mL).
Women of child-bearing potential, defined as all women physiologically capable of becoming pregnant, unwilling to use effective contraception during the study and for 16 weeks after stopping treatment.
Check Your Eligibility
Let’s see if you might be eligible for this study.
What is your age and gender ?
There are 178 Locations for this study
Birmingham Alabama, 35205, United States
Birmingham Alabama, 35233, United States
Phoenix Arizona, 85013, United States
Phoenix Arizona, 85032, United States
Los Angeles California, 90045, United States
Oceanside California, 92056, United States
Pasadena California, 91105, United States
San Diego California, 92103, United States
San Diego California, 92123, United States
Colorado Springs Colorado, 80915, United States
Snellville Georgia, 30078, United States
Indianapolis Indiana, 46256, United States
Topeka Kansas, 66606, United States
Louisville Kentucky, 40241, United States
Louisville Kentucky, 40291, United States
Ann Arbor Michigan, 48109, United States
Omaha Nebraska, 68144, United States
New York New York, 10029, United States
Rochester New York, 14623, United States
High Point North Carolina, 27262, United States
Warren Ohio, 44483, United States
Oregon City Oregon, 97045, United States
Portland Oregon, 97210, United States
Portland Oregon, 97223, United States
Duncansville Pennsylvania, 16635, United States
Philadelphia Pennsylvania, 19104, United States
Johnston Rhode Island, 02919, United States
Charleston South Carolina, 29407, United States
Kingsport Tennessee, 37660, United States
Nashville Tennessee, 37203, United States
Austin Texas, 78759, United States
Dallas Texas, 75231, United States
Dallas Texas, 75246, United States
Houston Texas, 77030, United States
San Antonio Texas, 78229, United States
Salt Lake City Utah, 84117, United States
Norfolk Virginia, 23507, United States
Caba Buenos Aires, C1062, Argentina
Caba Buenos Aires, C1122, Argentina
Caba Buenos Aires, C1181, Argentina
Caba Buenos Aires, C1425, Argentina
Buenos Aires , C1425, Argentina
Mendoza , M5502, Argentina
Kogarah New South Wales, 2217, Australia
Woolloongabba Queensland, 4102, Australia
Carlton Victoria, 3053, Australia
East Melbourne Victoria, 3002, Australia
Bruxelles , 1200, Belgium
Gent , 9000, Belgium
Liege , 4000, Belgium
Edmonton Alberta, T5K 1, Canada
Surrey British Columbia, V3V 0, Canada
Vancouver British Columbia, V5Z 4, Canada
Moncton New Brunswick, E1C 8, Canada
Halifax Nova Scotia, B3H 1, Canada
Hamilton Ontario, L8N 1, Canada
Markham Ontario, L3P 1, Canada
Peterborough Ontario, K9J 5, Canada
Richmond Hil Ontario, L4B 1, Canada
Waterloo Ontario, N2J 1, Canada
Montreal Quebec, H3H 1, Canada
Sainte-Foy Quebec, G1V 4, Canada
Barranquilla Atlantico, , Colombia
Barranquilla , , Colombia
Bogota , 11022, Colombia
Tallinn , 10138, Estonia
Tallinn , 13419, Estonia
Tartu , 51014, Estonia
Helsinki , 00250, Finland
Paris Cedex 10 Cedex 10, 75475, France
Bordeaux Cedex , 33075, France
Marseille Cedex 9 , 13913, France
Martigues , 13500, France
Nice Cedex 3 , 06202, France
Reims , 51090, France
Toulouse Cedex , 31400, France
Koeln Nordrhein-Westfalen, 50937, Germany
Augsburg , 86179, Germany
Berlin , 10117, Germany
Berlin , 10789, Germany
Berlin , 13187, Germany
Bielefeld , 33647, Germany
Bochum , 44791, Germany
Bochum , 44793, Germany
Bonn , 53105, Germany
Darmstadt , 64283, Germany
Dresden , 01307, Germany
Erfurt , 99089, Germany
Erlangen , 91054, Germany
Essen , 45122, Germany
Frankfurt , 60590, Germany
Gera , 07548, Germany
Goettingen , 37075, Germany
Greifswald , 17475, Germany
Hamburg , 20354, Germany
Hamburg , 22143, Germany
Hamburg , 22391, Germany
Hanau , 63450, Germany
Heidelberg , 69115, Germany
Kiel , 24105, Germany
Krefeld , 47805, Germany
Muenchen , 80802, Germany
Muenster , 48149, Germany
Osnabrueck , 49074, Germany
Plauen , 08529, Germany
Recklinghausen , 45657, Germany
Schwerin , 19055, Germany
Tuebingen , 72076, Germany
Wuppertal , 42275, Germany
Guatemala City , 01010, Guatemala
Guatemala City , 01015, Guatemala
Budapest , 1134, Hungary
Debrecen , 4032, Hungary
Kaposvar , 7400, Hungary
Miskolc , 3529, Hungary
Szeged , H-672, Hungary
Szombathely , 9700, Hungary
Kopavogur , 201, Iceland
Afula , 18341, Israel
Petach Tikva , 49100, Israel
Ramat Gan , 52656, Israel
Catania CT, 95123, Italy
Modena MO, 41124, Italy
Nagoya-city Aichi, 467-8, Japan
Fukuoka-city Fukuoka, 814-0, Japan
Kurume city Fukuoka, 830-0, Japan
Maebashi city Gunma, 371 8, Japan
Asahikawa-city Hokkaido, 078-8, Japan
Sapporo-city Hokkaido, 060-0, Japan
Kobe-City Hyogo, 654-0, Japan
Inashiki-gun Ibaraki, 300-0, Japan
Isehara-city Kanagawa, 259-1, Japan
Kawasaki-city Kanagawa, 213-8, Japan
Sagamihara-city Kanagawa, 228-8, Japan
Kyoto-city Kyoto, 602-8, Japan
Bunkyo ku Tokyo, 113 8, Japan
Chiyoda-ku Tokyo, 102-8, Japan
Minato-ku Tokyo, 105-8, Japan
Shinagawa-ku Tokyo, 141 8, Japan
Shinjuku-ku Tokyo, 160-0, Japan
Shinjuku-ku Tokyo, 160-8, Japan
Daejeon Korea, 35015, Korea, Republic of
Seoul Korea, 05505, Korea, Republic of
Seoul Korea, 06351, Korea, Republic of
Seoul Seocho-gu, 06591, Korea, Republic of
Busan , 49241, Korea, Republic of
Gwangju , 61469, Korea, Republic of
Seoul , 03722, Korea, Republic of
Seoul , 05030, Korea, Republic of
Seoul , 156-7, Korea, Republic of
Daugavpils LVA, LV-54, Latvia
Ventspils LVA, LV-36, Latvia
Riga , 1012, Latvia
Riga , LV-10, Latvia
Kaunas LTU, LT-50, Lithuania
Klaipeda LTU, 92304, Lithuania
Vilnius , LT-07, Lithuania
Vilnius , LT-08, Lithuania
Lodz , 90-26, Poland
Lodz , 90-43, Poland
Poznan , 60 52, Poland
Wroclaw , 50-36, Poland
Bucuresti , 04133, Romania
Singapore , 11907, Singapore
Sabadell Barcelona, 08208, Spain
Santa Coloma De Gramanet Cataluña, 08923, Spain
Valencia Comunidad Valenciana, 46014, Spain
Barcelona , 08041, Spain
Madrid , 28031, Spain
Madrid , 28041, Spain
Malmo , SE-20, Sweden
Uppsala , 751 8, Sweden
Hsin Chu , , Taiwan
Taichung , 40447, Taiwan
Taipei , 10002, Taiwan
Plymouth Devon, PL6 8, United Kingdom
London England, E11 1, United Kingdom
Salford Manchester, M6 8H, United Kingdom
Yeovil Somerset, BA21 , United Kingdom
Dudley West Midlands, DY1 2, United Kingdom
Harrogate , HG2 7, United Kingdom
Nuneaton , CV10 , United Kingdom
How clear is this clinincal trial information?

Please confirm you are a US based health care provider:
Yes, I am a health care Provider No, I am not a health care providerSign Up Now.
Take Control of Your Disease Journey.
Sign up now for expert patient guides, personalized treatment options, and cutting-edge insights that can help you push for the best care plan.