Psoriasis Clinical Trial

Immune Spatial Features of Guselkumab Cutaneous Response

Summary

This study examines the effect of IL-23 blockade with Guselkumab on the immune cells of scalp psoriasis lesions.

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Full Description

This is a one-arm, open-label study to examine the effect of Guselkumab . Guselkumab is a FDA-approved medication for the treatment of psoriasis. This study will examine how Guselkumab affects immune cells within scalp psoriasis lesions. Ten subjects with moderate to severe scalp psoriasis will be enrolled. Biopsy samples will be collected and undergo molecular profiling to correlate profiles with Guselkumab treatment response.

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Eligibility Criteria

Inclusion Criteria: possess a PSSI (psoriasis scalp severity index) of ≥12

Exclusion Criteria:

taking systemic immunosuppressives in the last 4 weeks
pregnancy
severe immunodeficiency (either from genetic or infectious causes).
tuberculosis or other active serious infection
active systemic malignancy.
breast-feeding
Presence of a condition or abnormality that in the opinion of the Investigator would compromise the safety of the patient or the quality of the data.

Males who are trying to conceive

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Study is for people with:

Psoriasis

Phase:

Phase 4

Estimated Enrollment:

10

Study ID:

NCT05858632

Recruitment Status:

Recruiting

Sponsor:

University of California, San Francisco

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There is 1 Location for this study

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University of California San Francisco
San Francisco California, 94115, United States More Info
Jeffrey Cheng, MD, PhD
Contact
415-575-0524
[email protected]

How clear is this clinincal trial information?

Study is for people with:

Psoriasis

Phase:

Phase 4

Estimated Enrollment:

10

Study ID:

NCT05858632

Recruitment Status:

Recruiting

Sponsor:


University of California, San Francisco

How clear is this clinincal trial information?

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