Psoriasis Clinical Trial

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Psoriatic Immune Response to Tildrakizumab

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Summary

This study aims to assess cutaneous and blood immune cell function of patients with psoriasis before and after initiation of treatment with the IL23 blocker, tildrakizumab.

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Full Description

This is a one-arm, open-label study to examine the effect of Tildrakizumab on cutaneous and blood immune cells of psoriatic patients. Ten subjects with moderate to severe psoriasis will be enrolled. Biopsy and blood samples will be collected before and during treatment and undergo molecular profiling to assess for tildrakizumab-corrected signatures.

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Eligibility Criteria

Inclusion Criteria:

18 years of age or older
Patients with moderate-severe psoriasis or > 5% body surface area affected.

Exclusion Criteria:

taking systemic immunosuppressives in the last 4 weeks
pregnancy
severe immunodeficiency (either from genetic or infectious causes).
tuberculosis or other active serious infection
active systemic malignancy.
breast-feeding
Presence of a condition or abnormality that in the opinion of the Investigator would compromise the safety of the patient or the quality of the data.

Study is for people with:

Psoriasis

Phase:

Phase 4

Estimated Enrollment:

10

Study ID:

NCT05390515

Recruitment Status:

Recruiting

Sponsor:

University of California, San Francisco

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There is 1 Location for this study

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University of California, San Francisco
San Francisco California, 94115, United States More Info
Raymond Cho, MD, PhD
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How clear is this clinincal trial information?

Study is for people with:

Psoriasis

Phase:

Phase 4

Estimated Enrollment:

10

Study ID:

NCT05390515

Recruitment Status:

Recruiting

Sponsor:


University of California, San Francisco

How clear is this clinincal trial information?

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